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Titolo:
Cholesterol efflux capacity in vitro predicts the severity and extent of coronary artery disease in patients with and without type 2 diabetes
Autore:
Pajunen, P; Syvanne, M; Castro, G; Nieminen, MS; Taskinen, MR;
Indirizzi:
Univ Helsinki, Cent Hosp, Div Cardiol, Dept Med, FI-00029 Helsinki, Finland Univ Helsinki Helsinki Finland FI-00029 Med, FI-00029 Helsinki, Finland INSERM, Inst Pasteur, F-59045 Lille, France INSERM Lille France F-59045INSERM, Inst Pasteur, F-59045 Lille, France
Titolo Testata:
SCANDINAVIAN CARDIOVASCULAR JOURNAL
fascicolo: 2, volume: 35, anno: 2001,
pagine: 96 - 100
SICI:
1401-7431(200103)35:2<96:CECIVP>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY-LIPOPROTEIN; PRE-BETA PARTICLE; I-A-II; LPA-I; HUMAN SERUM; TRANSPORT; MUTATIONS; CELLS; DEFICIENCY; MELLITUS;
Keywords:
cholesterol efflux; coronary angiography; coronary disease; diabetes mellitus; type 2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Syvanne, M Univ Helsinki, Cent Hosp, Div Cardiol, Dept Med, POB 340,Haartmaninkatu 4,FI-00029 Helsinki, Finland Univ Helsinki POB 340,Haartmaninkatu 4 Helsinki Finland FI-00029
Citazione:
P. Pajunen et al., "Cholesterol efflux capacity in vitro predicts the severity and extent of coronary artery disease in patients with and without type 2 diabetes", SC CARDIOVA, 35(2), 2001, pp. 96-100

Abstract

Objective-To investigate the relation between severity and extent of coronary artery disease (CAD) and in vitro cholesterol efflux capacity. Design-This study consisted of 46 type 2 diabetic, and 42 nondiabetic men undergoing coronary angiography, Quantitative coronary angiography was usedto estimate the severity, extent, and overall "atheroma burden" of CAD. The capacity of patient plasma to induce cholesterol efflux from cultured Fu5AH rat hepatoma cells was measured in vitro. Results-In the combined study population (n = 88), there was a significantinverse correlation between efflux and global atheroma burden (r = -0.23, p < 0.05). In the diabetic group, the global atheroma burden index was independently associated both with cholesterol efflux and with LpA-I levels. However, in the nondiabetic CAD group this association was lost when efflux and LpA-I levels were included in the same model. Conclusion-The present study demonstrated that efflux capacity was inversely associated with the severity and extent of CAD. In the diabetic group this association was independent of LpA-I levels, suggesting impaired antiatherogenic potential of these particles in type 2 diabetic patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 22:07:13