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Titolo:
Thrombolytic therapy preserves vagal activity early after acute myocardialinfarction
Autore:
Lind, P; Hintze, U; Moller, M; Mickley, H;
Indirizzi:
Odense Univ Hosp, Dept Cardiol, DK-5000 Odense C, Denmark Odense Univ Hosp Odense Denmark C ept Cardiol, DK-5000 Odense C, Denmark
Titolo Testata:
SCANDINAVIAN CARDIOVASCULAR JOURNAL
fascicolo: 2, volume: 35, anno: 2001,
pagine: 92 - 95
SICI:
1401-7431(200103)35:2<92:TTPVAE>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-RATE-VARIABILITY; VENTRICULAR EJECTION FRACTION; SIGNAL-AVERAGED ELECTROCARDIOGRAM; RISK STRATIFICATION; ARRHYTHMIC EVENTS; PROGNOSTIC-SIGNIFICANCE; PERIOD VARIABILITY; MORTALITY; PREDICTION; ISCHEMIA;
Keywords:
acute myocardial infarction; heart rate variability; thrombolysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Mickley, H Odense Univ Hosp, Dept Cardiol, DK-5000 Odense C, Denmark Odense Univ Hosp Odense Denmark C , DK-5000 Odense C, Denmark
Citazione:
P. Lind et al., "Thrombolytic therapy preserves vagal activity early after acute myocardialinfarction", SC CARDIOVA, 35(2), 2001, pp. 92-95

Abstract

Objective-The purpose of this study was to evaluate the effects of thrombolytic therapy on vagal tone after acute myocardial infarction (AMI),Design-Holter monitoring for 24 h was performed at hospital discharge and 6 weeks after AMI in 74 consecutive male survivors of a first AMI, who fulfilled established criteria for thrombolytic therapy. Thirty-five patients received thrombolyses, while the remaining 39 patients did not (controls). In each Holter recording 24-h heart rate variability was calculated as pNN50, which represents the percentage of successive RR interval differences > 50 ms. Alterations in pNN50 are known to reflect changes in vagal tone. Results-The analysis showed that controls early after AMI had low pNN50 values without any diurnal changes. Six weeks after AMI pNN50 values in controls exhibited a circadian rhythm with higher values during night-time. Thispattern was similar to the pattern observed in thrombolysed patients earlyafter AMI, In thrombolysed patients pNN50 values, particularly at night, were further improved 6 weeks after AMI (p = 0.037). Conclusion-These observations indicate that thrombolytic therapy, given for a first AMI, preserves vagal activity when compared with patients who arenot thrombolysed, The enhanced parasympathetic tone may be a part of the beneficial mechanisms responsible for the reduction in mortality after thrombolysis in AMI.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 17:20:36