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Titolo:
Carcinogen-specific induction of genetic instability
Autore:
Bardelli, A; Cahill, CP; Lederer, G; Speicher, MR; Kinzler, KW; Vogelstein, B; Lengauer, C;
Indirizzi:
Johns Hopkins Oncol Ctr, Baltimore, MD 21231 USA Johns Hopkins Oncol Ctr Baltimore MD USA 21231 r, Baltimore, MD 21231 USA Howard Hughes Med Inst, Baltimore, MD 21231 USA Howard Hughes Med Inst Baltimore MD USA 21231 st, Baltimore, MD 21231 USA Grad Program Human Genet & Mol Biol, Baltimore, MD 21231 USA Grad Program Human Genet & Mol Biol Baltimore MD USA 21231 , MD 21231 USA Univ Munich, Inst Anthropol & Human Genet, D-80333 Munich, Germany Univ Munich Munich Germany D-80333 Human Genet, D-80333 Munich, Germany
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 10, volume: 98, anno: 2001,
pagine: 5770 - 5775
SICI:
0027-8424(20010508)98:10<5770:CIOGI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
MISMATCH REPAIR; HETEROCYCLIC AMINES; COLON-CANCER; COOKED FOODS; RISK; MUTATIONS; CELLS; 2-AMINO-1-METHYL-6-PHENYLIMIDAZO<4,5-B>PYRIDINE; IDENTIFICATION; SELECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Lengauer, C Johns Hopkins Oncol Ctr, 1650 Orleans St, Baltimore, MD 21231 USA Johns Hopkins Oncol Ctr 1650 Orleans St Baltimore MD USA 21231
Citazione:
A. Bardelli et al., "Carcinogen-specific induction of genetic instability", P NAS US, 98(10), 2001, pp. 5770-5775

Abstract

It has been proposed recently that the type of genetic instability in cancer cells reflects the selection pressures exerted by specific carcinogens. We have tested this hypothesis by treating immortal, genetically stable human cells with representative carcinogens. We found that cells resistant to the bulky-adduct-forming agent 2-amino-1 -methyl-6-phenylimidazo[4,5-b]pyridine (PhlP) exhibited a chromosomal instability (CIN), whereas cells resistant to the methylating agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) exhibited a microsatellite instability (MIN) associated with mismatch repair defects. Conversely, we found that cells purposely made into CIN cells are resistant to PhlP, whereas MIN cells are resistant to MNNG. These data demonstrate that exposure to specific carcinogens can indeed select for tumor cells with distinct forms of genetic instability and vice versa.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:49:20