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Titolo:
Role of central histaminergic system in lorazepam withdrawal syndrome in rats
Autore:
Nath, C; Gupta, MB;
Indirizzi:
Cent Drug Res Inst, Div Pharmacol, Lucknow 226001, Uttar Pradesh, India Cent Drug Res Inst Lucknow Uttar Pradesh India 226001 ttar Pradesh, India KG Med Coll, Dept Pharmacol, CDRI, Neuropharmacol Unit, Lucknow 226003, Uttar Pradesh, India KG Med Coll Lucknow Uttar Pradesh India 226003 6003, Uttar Pradesh, India
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 4, volume: 68, anno: 2001,
pagine: 777 - 782
SICI:
0091-3057(200104)68:4<777:ROCHSI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEIZURES; ANTAGONISTS; MICE;
Keywords:
benzodiazepine; physical dependence; withdrawal syndrome; histamine; H1 receptor; H3 receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Nath, C Cent Drug Res Inst, Div Pharmacol, POB 173, Lucknow 226001, Uttar Pradesh,India Cent Drug Res Inst POB 173 Lucknow Uttar Pradesh India 226001ndia
Citazione:
C. Nath e M.B. Gupta, "Role of central histaminergic system in lorazepam withdrawal syndrome in rats", PHARM BIO B, 68(4), 2001, pp. 777-782

Abstract

Effects of histaminergic agonists and antagonists were investigated on withdrawal signs in lorazepam-dependent rats. Physical dependence was developed by giving lorazepam admired with the food in the following dose schedule (in mg/kg given daily x days): 10 x 4, 20 x 4, 40 x 4, 80 x 4, and 120 x 7. The parameters observed during the periods of administration of lorazepam acid after its withdrawal were spontaneous locomotor activity (SLA), reaction time to pain, foot shock aggression (FSA), and audiogenic seizures. During the withdrawal period, the rats were divided into groups of 10 each. Control-withdrawal group did not receive any drug. The drugs (in mg/kg administered intramuscularly)-L-histidine (50), histamine-N-methy (2), promethazine (10), pheniramine (10), astemizole (10), and thioperamide (1)-were given separately in other groups daily during the withdrawal period. The withdrawal signs in control group were hyperkinesia. hyperaggression, and audiogenic seizures. L-Histidine, precursor of histamine, and thioperamide, antagonist of H3 receptor, potentiated hyperkinesia, hyperaggression, and audiogenic seizures. Histamine-N-methyl, agonist of H3 receptor, and H1 receptor antagonists, promethazine and pheniramine, blocked all the withdrawal signs. Astemizole, a peripheral antagonist of H1 receptor, could not affect any withdrawal sign. It may be concluded that histamine H1 receptors are facilitatory and H3 receptors are inhibitory for benzodiazepine (BZD) withdrawal syndrome. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 21:16:36