Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Different treatment regimens and the development of tolerance to nicotine's anxiogenic effects
Autore:
Irvine, EE; Cheeta, S; Marshall, M; File, SE;
Indirizzi:
Univ London Kings Coll, GKT Sch Biomed Sci, Ctr Neurosci, Psychopharmacol Res Unit, London SE1 1UL, England Univ London Kings Coll London England SE1 1UL t, London SE1 1UL, England
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 4, volume: 68, anno: 2001,
pagine: 769 - 776
SICI:
0091-3057(200104)68:4<769:DTRATD>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELEVATED PLUS-MAZE; SOCIAL-INTERACTION TEST; STRIATAL SYNAPTOSOMES; DORSAL HIPPOCAMPUS; DOPAMINE RELEASE; ANXIETY; RATS; COCAINE; DESENSITIZATION; SENSITIZATION;
Keywords:
nicotine; anxiety; tolerance; treatment regimen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: File, SE Univ London Kings Coll, GKT Sch Biomed Sci, Ctr Neurosci, Psychopharmacol Res Unit, Hodgkin Bldg,Guys Campus, London SE1 1UL, England Univ London Kings Coll Hodgkin Bldg,Guys Campus London England SE1 1UL
Citazione:
E.E. Irvine et al., "Different treatment regimens and the development of tolerance to nicotine's anxiogenic effects", PHARM BIO B, 68(4), 2001, pp. 769-776

Abstract

The effects of different treatment regimens were investigated on the development of tolerance to the anxiogenic effect of nicotine (0.45 mg/kg) in the social interaction test of anxiety. Rats received nicotine (0.45 mg/kg/day) by intravenous injections (5 days/week), subcutaneous injections (5 or 7days/week) or continuous infusion by osmotic minipump. In all groups, 4 days of nicotine treatment resulted in significant decreases in social interaction compared with the vehicle control groups, without changes in locomotor activity, indicating a specific anxiogenic effect. These significant anxiogenic effects persisted even after 4 weeks of treatment although they wereless marked, indicating development of partial tolerance. No significant changes in the time spent in social interaction were found when rats were tested undrugged 24 and 72 h after the termination of nicotine treatment. There was no evidence that the treatment regimen affected the rate of development of tolerance, despite very different peak plasma nicotine concentrations. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 01:03:57