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Titolo:
Prepulse inhibition of the acoustic startle response in cocaine-withdrawn rats
Autore:
Adams, JU; Efferen, TR; Duncan, EJ; Rotrosen, J;
Indirizzi:
NYU, Sch Med, Dept Psychiat, New York Harbor Dept Vet Affairs Hlth Care Syst, New York, NY 10010 USA NYU New York NY USA 10010 Affairs Hlth Care Syst, New York, NY 10010 USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 4, volume: 68, anno: 2001,
pagine: 753 - 759
SICI:
0091-3057(200104)68:4<753:PIOTAS>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANIMAL-MODEL; INTERMITTENT; EXPOSURE; SENSITIZATION; STIMULATION; ANXIETY; BRAIN;
Keywords:
cocaine; withdrawal; startle reaction; prepulse inhibition; sensory gating; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Adams, JU NYU Med Ctr, VAMC, 423 E 23rd St, New York, NY 10010 USA NYU MedCtr 423 E 23rd St New York NY USA 10010 rk, NY 10010 USA
Citazione:
J.U. Adams et al., "Prepulse inhibition of the acoustic startle response in cocaine-withdrawn rats", PHARM BIO B, 68(4), 2001, pp. 753-759

Abstract

Prepulse inhibition (PPI) of startle is a sensorimotor gating task in which a low-intensity acoustic stimulus presented prior to a high-intensity, startle-eliciting stimulus can attenuate the acoustic startle response (ASR). Previous studies on startle reactivity in cocaine-withdrawn rats have found minimal changes; the present study extends this work to the gating of ASR. In Experiment 1, rats were injected daily with either saline or cocaine (30 mg/kg ip) for 2 weeks. ASR and PPI were measured prior to, and at 3- and11-day withdrawal from, the chronic treatment. No effect of cocaine treatment was found on either measure. In Experiment 2, treatment was extended to8 weeks, and an earlier withdrawal time point (1 day) was added. Rats treated with cocaine for 8 weeks exhibited lower startle reactivity during withdrawal compared with saline-treated controls. PPI did not differ between treatment groups. Thus, extended chronic treatment with cocaine rendered significant effects on startle responsivity. Further, this finding mirrors the blunted ASR exhibited in chronic cocaine users [Neuropsychopharmacology 22 (2000) 89.]. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:28:45