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Titolo:
Amlodipine enhances the activity of antiepileptic drugs against pentylenetetrazole-induced seizures
Autore:
Kaminski, RM; Mazurek, M; Turski, WA; Kleinrok, Z; Czuczwar, SJ;
Indirizzi:
Med Univ, Dept Pathophysiol, PL-20090 Lublin, Poland Med Univ Lublin Poland PL-20090 pt Pathophysiol, PL-20090 Lublin, Poland Inst Agr Med, Isotope Lab, Lublin, Poland Inst Agr Med Lublin PolandInst Agr Med, Isotope Lab, Lublin, Poland Med Univ, Dept Rheumatol, Lublin, Poland Med Univ Lublin PolandMed Univ, Dept Rheumatol, Lublin, Poland Med Univ, Dept Pharmacol & Toxicol, Lublin, Poland Med Univ Lublin Poland d Univ, Dept Pharmacol & Toxicol, Lublin, Poland Inst Agr Med, Dept Toxicol, Lublin, Poland Inst Agr Med Lublin PolandInst Agr Med, Dept Toxicol, Lublin, Poland
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 4, volume: 68, anno: 2001,
pagine: 661 - 668
SICI:
0091-3057(200104)68:4<661:AETAOA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALCIUM-CHANNEL BLOCKERS; RAT SENSORY NEURONS; THALAMIC NEURONS; PHARMACOLOGICAL PROPERTIES; ANTICONVULSANT EFFICACY; BRAIN PHARMACOKINETICS; ANIMAL-MODELS; LOW-THRESHOLD; MICE; NIMODIPINE;
Keywords:
calcium antagonists; amlodipine; antiepileptic drugs; seizures; pentylenetetrazole;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Czuczwar, SJ Med Univ, Dept Pathophysiol, Jaczewskiego 8, PL-20090 Lublin,Poland Med Univ Jaczewskiego 8 Lublin Poland PL-20090 ublin, Poland
Citazione:
R.M. Kaminski et al., "Amlodipine enhances the activity of antiepileptic drugs against pentylenetetrazole-induced seizures", PHARM BIO B, 68(4), 2001, pp. 661-668

Abstract

Amlodipine (AML), which belongs to the 1,4-dihydropyridin calcium channel antagonists, possesses pharmacological and pharmacokinetic profile that distinguishes it from other agents of this class. Pentylenetetrazole (PTZ)-induced clonic and tonic convulsions in mice were significantly reduced by administration of AML at 10 mg/kg. At this dose AML remained without influenceupon the plasma level of PTZ. The ED50 value of AML against clonic seizures induced by PTZ was 5.4 mg/kg. This calcium channel antagonist (at 2.5 mg/kg) combined with ethosuximide (ETX), valproate magnesium (VPA) or phenobarbital (PB) significantly reduced their ED50 values against clonic phase of PTZ-induced seizures. AML administered alone or in combination with antiepileptic drugs (AEDs) worsened the motor performance of mice in the chimney test. However, these treatments remained without significant influence on the retention time in the passive avoidance test. Plasma levels of antiepileptics remained unchanged in the presence of AML. The results indicate that AML does not seem a good candidate for a combination therapy in epileptic patients because of its adverse potential. (C) 2001 Elsevier Science Inc. Allrights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:12:54