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Titolo:
Effect of the kappa-opioid receptor agonist, U69593, on reinstatement of extinguished amphetamine self-administration behavior
Autore:
Schenk, S; Partridge, B;
Indirizzi:
Texas A&M Univ, Dept Psychol, College Stn, TX 77843 USA Texas A&M Univ College Stn TX USA 77843 sychol, College Stn, TX 77843 USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 4, volume: 68, anno: 2001,
pagine: 629 - 634
SICI:
0091-3057(200104)68:4<629:EOTKRA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; EXTRACELLULAR DOPAMINE; NUCLEUS-ACCUMBENS; PREFRONTAL CORTEX; SQUIRREL-MONKEYS; SENSITIZES RATS; RHESUS-MONKEYS; COCAINE; MODULATION; MU;
Keywords:
amphetamine; cocaine; drug seeking; relapse; U69593; kappa-opioid receptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Schenk, S Texas A&M Univ, Dept Psychol, College Stn, TX 77843 USA Texas A&M Univ College Stn TX USA 77843 llege Stn, TX 77843 USA
Citazione:
S. Schenk e B. Partridge, "Effect of the kappa-opioid receptor agonist, U69593, on reinstatement of extinguished amphetamine self-administration behavior", PHARM BIO B, 68(4), 2001, pp. 629-634

Abstract

Previous research has indicated that pretreatment with the kappa-opioid receptor agonist, U69593, decreased the ability of experimenter-administered cocaine to reinstate extinguished cocaine self-administration behavior. This effect was specific to cocaine-produced drug seeking since U69593 failed to attenuate the ability of experimenter-administered amphetamine to reinstate extinguished cocaine self-administration behavior. One possibility is that U69593 selectively attenuates the behavioral effects of the drug that was originally self-administered. In order to test this hypothesis, the present study examined the effect of U69593 (0.0 or 0.32 mg/kg) on the reinstatement of extinguished amphetamine self-administration behavior produced by experimenter-administered injections of cocaine and amphetamine. Following extinction of amphetamine self-administration (0.04 mg/kg/infusion) the ability of cocaine (0.0, 5.0, 10.0 or 20.0 mg/kg) or amphetamine (0.0, 0.3, 1.0 or 3.0 mg/kg) to reinstate extinguished self-administration behavior was measured. Both drugs reinstated extinguished responding and the reinstatement was attenuated by pretreatment with U69593. The data indicate that the ability of U69593 to decrease drug seeking is not restricted to subjects experienced with cocaine self-administration Self-administration history does,however, determine the effect of U69593 on amphetamine-produced drug seeking. (C) 2001 Elsevier Science Inc. All rights reserved.

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Documento generato il 07/04/20 alle ore 21:11:09