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Titolo:
Bronchoalveolar inflammation following airway infection in preterm infantswith chronic lung disease
Autore:
Groneck, P; Schmale, J; Soditt, V; Stutzer, H; Gotze-Speer, B; Speer, CP;
Indirizzi:
Childrens Hosp City Cologne, Dept Neonatol, D-50735 Cologne, Germany Childrens Hosp City Cologne Cologne Germany D-50735 735 Cologne, Germany Univ Hosp, Inst Med Stat Informat & Epidemiol, Cologne, Germany Univ HospCologne Germany d Stat Informat & Epidemiol, Cologne, Germany Childrens Hosp, Dept Pediat, Wurzburg, Germany Childrens Hosp Wurzburg Germany ns Hosp, Dept Pediat, Wurzburg, Germany
Titolo Testata:
PEDIATRIC PULMONOLOGY
fascicolo: 5, volume: 31, anno: 2001,
pagine: 331 - 338
SICI:
8755-6863(200105)31:5<331:BIFAII>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS SYNDROME; UREAPLASMA-UREALYTICUM COLONIZATION; TUMOR-NECROSIS-FACTOR; BRONCHOPULMONARY DYSPLASIA; PREMATURE-INFANTS; POTENTIAL ROLE; FACTOR-ALPHA; INTERLEUKIN-6; MEDIATORS; LAVAGE;
Keywords:
neonatal chronic lung disease; bronchopulmonary dysplasia; airway infection; pulmonary inflammation; Ureaplasma urealyticum; interleukins; bronchoalveolar lavage; mediators;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Groneck, P Childrens Hosp City Cologne, Dept Neonatol, Amsterdamer St 59, D-50735 Cologne, Germany Childrens Hosp City Cologne Amsterdamer St 59 Cologne Germany D-50735
Citazione:
P. Groneck et al., "Bronchoalveolar inflammation following airway infection in preterm infantswith chronic lung disease", PEDIAT PULM, 31(5), 2001, pp. 331-338

Abstract

Chronic lung disease (CLD) of the newborn is associated with pulmonary inflammation. However, the origin of this inflammation is not known. We evaluated the impact of airway infection on bronchoalveolar inflammation in mechanically ventilated preterm infant at risk for CLD (n = 68). Mean and maximum concentrations of the inflammatory mediators (IM) interleukin-l and interleukin-8 were assayed in the tracheobronchial aspirate fluid (TAF) of neonates with perinatal airway infection (Ureaplasma urealyticum, or bacteria), postnatal nosocomial airway infection, or respiratory disease without airway infection from days 1-10 of postnatal age. Patients with CLD (n = 23;) exhibited increased levels of IM in TAF compared to neonates without CLD. Within the three subgroups, concentrations of IM were increased in CLD patients with perinatal infection and in CLD patients with respiratory disease without airway infection, but not in CLD patients with nosocomial airway infection. Although airway colonization with Gramnegative bacteria was more frequently found in CLD patients within the first month of life, there were no differences between levels of IM in patientscolonized with Gram-negative bacteria or coagulase-negative staphyloccoci. We conclude that perinatal infections with Ureaplasma urealyticum or bacteria and respiratory disease without infection, but not nosocomial airway infection, contribute to the bronchopulmonary inflammatory response in neonates with CLD. (C) 2001 Wiley-Liss. Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 12:09:33