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Titolo:
Distribution of alpha(2)-adrenergic receptor binding in the developing human brain stem
Autore:
Mansouri, J; Panigrahy, A; Assmann, SF; Kinney, HC;
Indirizzi:
Childrens Hosp, Dept Pathol, Boston, MA 02115 USA Childrens Hosp Boston MA USA 02115 osp, Dept Pathol, Boston, MA 02115 USA Harvard Univ, Sch Med, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 vard Univ, Sch Med, Boston, MA 02115 USA Childrens Hosp, Dept Neurol, Boston, MA 02115 USA Childrens Hosp Boston MA USA 02115 osp, Dept Neurol, Boston, MA 02115 USA New England Res Inst, Ctr Stat Anal & Res, Watertown, MA 02472 USA New England Res Inst Watertown MA USA 02472 Res, Watertown, MA 02472 USA
Titolo Testata:
PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
fascicolo: 3, volume: 4, anno: 2001,
pagine: 222 - 236
SICI:
1093-5266(200105/06)4:3<222:DOARBI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFANT-DEATH-SYNDROME; NUCLEUS-TRACTUS-SOLITARIUS; CENTRAL-NERVOUS-SYSTEM; MESSENGER-RNA EXPRESSION; H-3 RX821002 BINDING; LOCUS-COERULEUS; RAT-BRAIN; ALPHA-2-ADRENERGIC RECEPTOR; AUTORADIOGRAPHIC LOCALIZATION; VENTROLATERAL MEDULLA;
Keywords:
nucleus of the solitary tract; receptor autoradiography; respiratory control; imidazoline receptors; intermediate reticular zone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Kinney, HC Childrens Hosp, Dept Pathol, 300 Longwood Ave, Boston, MA 02115USA Childrens Hosp 300 Longwood Ave Boston MA USA 02115 A 02115 USA
Citazione:
J. Mansouri et al., "Distribution of alpha(2)-adrenergic receptor binding in the developing human brain stem", PEDIATR D P, 4(3), 2001, pp. 222-236

Abstract

Rapid and dramatic changes occur in cardiorespiratory function during early human life. Catecholamines within select brain stem nuclei are implicatedin the control of autonomic and respiratory function, including in the nucleus of the solitary tract and the dorsal motor nucleus of X. Animal and adult human studies have shown high binding to alpha (2)-adrenergic receptorsin these regions. To determine the developmental profile of brainstem alpha (2)-adrenergic binding across early human life, we studied brain stems from five fetuses at midgestation, three newborns (37-38 postconceptional weeks), and six infants (44-61 postconceptional weeks). We used quantitative tissue receptor autoradiography with [H-3]para-aminoclonidine as the radioligand and phentolamine as the displacer. In the fetal group, binding was high (63-93 fmol/mg tissue) in the nucleus of the solitary tract. dorsal motornucleus of X, locus coeruleus, and reticular formation, it was low (< 32 fmol/mg tissue) in the principal inferior olive and basis pontis. Binding decreased in all regions with age: in infancy, the highest binding was in theintermediate range (32-62 fmol/mg tissue) and was localized to the nucleusof the solitary tract and dorsal motor nucleus of X. The most substantial decrease in binding (75%-85%) between the fetal and infant periods occurredin the pontine and medullary reticular formation and hypoglossal nucleus. Binding remained lour in the principal inferior olive and basis pontis. Thedecreases in binding with age remained significant after quench correction. These data suggest that rapid and dramatic changes occur in early human life in the brain stem catecholaminergic system in regions related to cardiorespiratory control.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 13:57:02