Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Mechanisms of antiarrhythmic drug action on termination of atrial flutter
Autore:
Tai, CT; Chen, SA;
Indirizzi:
Natl Yang Ming Univ, Sch Med, Dept Med, Div Cardiol,Taipei Vet Gen Hosp, Taipei, Taiwan Natl Yang Ming Univ Taipei Taiwan l,Taipei Vet Gen Hosp, Taipei, Taiwan
Titolo Testata:
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
fascicolo: 5, volume: 24, anno: 2001,
pagine: 824 - 834
SICI:
0147-8389(200105)24:5<824:MOADAO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIOFREQUENCY CATHETER ABLATION; STERILE PERICARDITIS MODEL; ACTION-POTENTIAL DURATION; CLASS-III AGENT; INTRAVENOUS IBUTILIDE; EXCITABLE GAP; REFRACTORY PERIOD; CIRCUS MOVEMENT; SLOW CONDUCTION; ELECTROPHYSIOLOGIC CHARACTERISTICS;
Keywords:
antiarrhythmic drugs; atrial flutter;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
93
Recensione:
Indirizzi per estratti:
Indirizzo: Tai, CT Taipei Vet Gen Hosp, Dept Med, Div Cardiol, 201 Sec 2,Shih Pai Rd,Taipei,Taiwan Taipei Vet Gen Hosp 201 Sec 2,Shih Pai Rd Taipei Taiwan i,Taiwan
Citazione:
C.T. Tai e S.A. Chen, "Mechanisms of antiarrhythmic drug action on termination of atrial flutter", PACE, 24(5), 2001, pp. 824-834

Abstract

Atrial flutter is an important arrhythmia in clinical practice. Although the reentrant circuit of human typical atrial flutter is well characterized,the action of antiarrhythmic drugs on this tachycardia is less understood,Based on the recent clinical trials, pure Class III drugs like ibutilide or dofetilide are more effective in acute termination of human atrial flutter. than Class I drugs like procainamide or flecainide. The mechanisms of drug induced termination of atrial flutter include refractory block due to cycle length oscillation, fixed block due to a, reduced safety factor for conduction, or a collision of opposing wavefronts due to loss of the lateral boundaries or return reexcitation. Because ventricular proarrhythmia is a major concern with ibutilide or dofetilide therapy, development of new drugs with more specific target profiles is a future direction for. treatment of human atrial flutter.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 13:51:12