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Titolo:
Synthesis of protected L-4-[sulfono(difluoromethyl)]phenylalanine and its incorporation into a peptide
Autore:
Liu, SF; Dockendorff, C; Taylor, SD;
Indirizzi:
Univ Waterloo, Dept Chem, Waterloo, ON N2L 3G1, Canada Univ Waterloo Waterloo ON Canada N2L 3G1 em, Waterloo, ON N2L 3G1, Canada
Titolo Testata:
ORGANIC LETTERS
fascicolo: 10, volume: 3, anno: 2001,
pagine: 1571 - 1574
SICI:
1523-7060(20010517)3:10<1571:SOPLAI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-TYROSINE PHOSPHATASE-1B; SOLID-PHASE SYNTHESIS; SH2 DOMAINS; HIV-1 ENTRY; N-BOC; INHIBITORS; ANALOGS; PHOSPHOTYROSINE; PHOSPHOSERINE; DERIVATIVES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Taylor, SD Univ Waterloo, Dept Chem, 200 Univ Ave W, Waterloo, ON N2L 3G1,Canada Univ Waterloo 200 Univ Ave W Waterloo ON Canada N2L 3G1 Canada
Citazione:
S.F. Liu et al., "Synthesis of protected L-4-[sulfono(difluoromethyl)]phenylalanine and its incorporation into a peptide", ORG LETT, 3(10), 2001, pp. 1571-1574

Abstract

[GRAPHICS]A protected form of L-4-[sulfono(difluoromethyl)]phenylalanine (F(2)Smp), a novel non hydrolyzable phospho- and sulfotyrosine mimetic, was synthesized via electrophilic fluorination of a benzylic sulfonate followed by a Pd-catalyzed cross coupling reaction between the fluorinated sulfonate and the zincate of protected iodoalanine, F(2)Smp was incorporated into a peptide using solid-phase peptide synthesis techniques.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 14:16:51