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Titolo:
Redox control of AP-1-like factors in yeast and beyond
Autore:
Toone, WM; Morgan, BA; Jones, N;
Indirizzi:
Christie Hosp NHS Trust, CRC, Cell Regulat Grp, Paterson Inst Canc Res, Manchester M20 4BX, Lancs, England Christie Hosp NHS Trust Manchester Lancs England M20 4BX , Lancs, England Univ Newcastle Upon Tyne, Sch Med, Sch Biochem & Genet, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England Univ Newcastle Upon Tyne Newcastle Upon Tyne Tyne & Wear England NE2 4HH
Titolo Testata:
ONCOGENE
fascicolo: 19, volume: 20, anno: 2001,
pagine: 2336 - 2346
SICI:
0950-9232(20010430)20:19<2336:RCOAFI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXIDATIVE STRESS-RESPONSE; ATF1 TRANSCRIPTION FACTOR; ACTIVATED PROTEIN-KINASE; FISSION YEAST; SACCHAROMYCES-CEREVISIAE; SCHIZOSACCHAROMYCES-POMBE; NUCLEAR EXPORT; GENE-EXPRESSION; BUDDING YEAST; CELL-CYCLE;
Keywords:
AP-1; yeast; redox-control; stress;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Jones, N Christie Hosp NHS Trust, CRC, Cell Regulat Grp, Paterson Inst Canc Res, Wilmslow Rd, Manchester M20 4BX, Lancs, England Christie Hosp NHS Trust Wilmslow Rd Manchester Lancs England M20 4BX
Citazione:
W.M. Toone et al., "Redox control of AP-1-like factors in yeast and beyond", ONCOGENE, 20(19), 2001, pp. 2336-2346

Abstract

Cells have evolved complex and efficient strategies for dealing with variable and often-harsh environments. A key aspect of these stress responses isthe transcriptional activation of genes encoding defense and repair proteins. In yeast members of the AP-1 family of proteins are required for the transcriptional response to oxidative stress. This sub-family of AP-1 (calledyAP-1) proteins are sensors of the redox-state of the cell and are activated directly by oxidative stress conditions. yAP-1 proteins are bZIP-containing factors that share homology to the mammalian AP-1 factor complex and bind to very similar DNA sequence sites, The generation of reactive oxygen species and the resulting potential for oxidative stress is common to all aerobically growing organisms, Furthermore, many of the features of this response appear to be evolutionarily conserved and consequently the study of model organisms, such as yeast, will have widespread utility. The important structural features of these factors, signaling pathways controlling their activity and the nature of the target genes they control will be discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:33:29