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Titolo:
The role of tetramerization in p53 function
Autore:
Chene, P;
Indirizzi:
Novartis, CH-4002 Basel, Switzerland Novartis Basel Switzerland CH-4002Novartis, CH-4002 Basel, Switzerland
Titolo Testata:
ONCOGENE
fascicolo: 21, volume: 20, anno: 2001,
pagine: 2611 - 2617
SICI:
0950-9232(20010510)20:21<2611:TROTIP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-SUPPRESSOR P53; DNA-BINDING DOMAIN; GAIN-OF-FUNCTION; FRAUMENI LIKE FAMILY; XENOPUS-LAEVIS P53; OLIGOMERIZATION DOMAIN; MUTANT P53; WILD-TYPE; TRANSCRIPTIONAL ACTIVATION; IN-VITRO;
Keywords:
p53; tetramerization; cancer;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
105
Recensione:
Indirizzi per estratti:
Indirizzo: Chene, P Novartis, K125 420, CH-4002 Basel, Switzerland Novartis K125 420 Basel Switzerland CH-4002 2 Basel, Switzerland
Citazione:
P. Chene, "The role of tetramerization in p53 function", ONCOGENE, 20(21), 2001, pp. 2611-2617

Abstract

The tumour suppressor gene p53 is extensively studied for its importance in cancer, In its active conformation, p53 is tetrameric and one domain - the tetramerization domain - permits the oligomerization of this protein. Until recently, little attention was given to this domain because, in contrastto the DNA-binding domain, it is not often mutated in cancer, However, various experimental studies have shown evidence that the tetramerization domain is essential for DNA binding, protein-protein interactions, post-translational modifications, and p53 degradation. Moreover, single mutations in the tetramerization domain can inactivate the wild-type protein in a manner similar to that seen with mutations in the DNA-binding domain, Interestingly, the phenotype of several tetramerization domain mutants differs from thatobserved with DNA-binding domain mutants. In this review, current knowledge about the importance of the tetramerization domain to the function of p53will be summarized.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:30:09