Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The Apolipoprotein E genotype in patients affected by syndromes with focalcortical atrophy
Autore:
Masullo, C; Daniele, A; Fazio, VM; Seripa, D; Gravina, C; Filippini, V; Grossi, D; Fragassi, N; Nichelli, P; Leone, M; Gainotti, G;
Indirizzi:
Univ Rome, Policlin A Gemelli, Ist Neurol, I-00168 Rome, Italy Univ Rome Rome Italy I-00168 A Gemelli, Ist Neurol, I-00168 Rome, Italy Univ Rome, Mol Med Lab, Rome, Italy Univ Rome Rome ItalyUniv Rome, Mol Med Lab, Rome, Italy IRCCS H Casa Sollievo Sofferenza, Lab Patol Mol, S Giovanni Rotondo, FG, Italy IRCCS H Casa Sollievo Sofferenza S Giovanni Rotondo FG Italy , FG, Italy IRCCS S Lucia, Rome, Italy IRCCS S Lucia Rome ItalyIRCCS S Lucia, Rome, Italy Univ Naples Federico II, Dipartimento Sci Neurol, Naples, Italy Univ Naples Federico II Naples Italy rtimento Sci Neurol, Naples, Italy Univ Modena, Neurol Clin, Modena, Italy Univ Modena Modena ItalyUniv Modena, Neurol Clin, Modena, Italy
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2, volume: 303, anno: 2001,
pagine: 87 - 90
SICI:
0304-3940(20010504)303:2<87:TAEGIP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; FRONTOTEMPORAL DEMENTIA; LOBAR ATROPHY; ALLELE; DEGENERATION; DIAGNOSIS; EPSILON-2; RISK; GENE;
Keywords:
Apolipoprotein E genotype; Alzheimer's disease; fronto-temporal dementia; primary progressive aphasia; corticobasal degeneration; focal cortical atrophy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Masullo, C Univ Cattolica Sacro Cuore, Ist Neurol, Largo A Gemelli 8, I-00168 Rome, Italy Univ Cattolica Sacro Cuore Largo A Gemelli 8 Rome Italy I-00168
Citazione:
C. Masullo et al., "The Apolipoprotein E genotype in patients affected by syndromes with focalcortical atrophy", NEUROSCI L, 303(2), 2001, pp. 87-90

Abstract

The role of the Apolipoprotein E (APOE) alleles in syndromes associated with focal cerebral atrophy (fronto-temporal dementia, primary progressive aphasia, corticobasal degeneration) is still controversial. We studied the APOE allele distribution in 39 patients with clinically diagnosed syndromes associated with focal cerebral atrophy (FCA), in 50 patients with early-onset probable Alzheimer's disease (EOAD), and in 60 patients with late-onset probable AD (LOAD). The APOE genotype was determined from a blood sample, using polymerase chain reaction and restriction enzyme digestion. The APOE epsilon4 allele frequency was significantly higher in the EOAD (21.0%) and LOAD (33.3%) groups, but nor in the FCA group (5.1%), as compared with controls. In our population, the epsilon2 allele frequency was significantly higher in patients with FCA (12.8%) than in controls (4.8%). These results showthat the APOE epsilon4 allele is not a risk factor for syndromes associated with FCA. The potential role of the epsilon2 allele in these syndromes needs further investigation. (C) 2001 Published by Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 23:34:28