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Titolo:
Macronutrient-induced cascade of events leading to parallel changes in hypothalamic serotonin and insulin
Autore:
Orosco, M; Gerozissis, K;
Indirizzi:
Univ Paris 07, CNRS ESA 7059, F-75251 Paris 05, France Univ Paris 07 Paris France 05 7, CNRS ESA 7059, F-75251 Paris 05, France
Titolo Testata:
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
fascicolo: 2, volume: 25, anno: 2001,
pagine: 167 - 174
SICI:
0149-7634(200103)25:2<167:MCOELT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUTRAL AMINO-ACIDS; BRAIN-SEROTONIN; MONOAMINE METABOLISM; TRYPTOPHAN LEVELS; NEUROPEPTIDE-Y; FASTED RAT; MICRODIALYSIS; PLASMA; CONSUMPTION; GLUCOSE;
Keywords:
serotonin (5-HT); hypothalamic insulin; tryptophan; large neutral amino acids; feeding; macronutrients; paraventricular-ventromedial nuclei;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Orosco, M Univ Paris 07, CNRS ESA 7059, 2 Pl Jussieu, F-75251 Paris 05, France Univ Paris 07 2 Pl Jussieu Paris France 05 251 Paris 05, France
Citazione:
M. Orosco e K. Gerozissis, "Macronutrient-induced cascade of events leading to parallel changes in hypothalamic serotonin and insulin", NEUROSCI B, 25(2), 2001, pp. 167-174

Abstract

Extracellular serotonin (5-HT) and insulin from hypothalamic PVN-VMH region follow parallel changes in response to specific macronutrient ingestion. Possible independent or causal mechanisms have been investigated. A common primary event might be pancreatic insulin secretion for both insulin entry into the brain and 5-HT synthesis through variations in the ratio of tryptophan over competitor amino acids. The steps of this cascade were found to account only partly for the changes in hypothalamic 5-HT and insulin. The central consequences of these metabolic effects may be modulated directly at the hypothalamic level. For instance, we observed a positive relation between the changes in insulin and 5-HT and the satiating potency of each nutrient. In addition, a direct action of dexfenfluramine on insulin has been found at the hypothalamic level showing that an activation of the serotonergicsystem immediately enhances insulin levels. This central event may be an important step in a cascade of events triggered by macronutrient ingestion leading to common hypothalamic insulin and 5-HT changes involved in feeding regulation. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:33:21