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Titolo:
EEG alpha rhythm and glucose metabolic rate in the thalamus in schizophrenia
Autore:
Danos, P; Guich, S; Abel, L; Buchsbaum, MS;
Indirizzi:
Univ Magdeburg, Dept Psychiat, D-39120 Magdeburg, Germany Univ Magdeburg Magdeburg Germany D-39120 iat, D-39120 Magdeburg, Germany Mt Sinai Med Ctr, Neurosci PET Lab, New York, NY 10029 USA Mt Sinai Med Ctr New York NY USA 10029 ci PET Lab, New York, NY 10029 USA Univ Calif Irvine, Brain Imaging Ctr, Irvine, CA USA Univ Calif Irvine Irvine CA USA rvine, Brain Imaging Ctr, Irvine, CA USA
Titolo Testata:
NEUROPSYCHOBIOLOGY
fascicolo: 4, volume: 43, anno: 2001,
pagine: 265 - 272
SICI:
0302-282X(2001)43:4<265:EARAGM>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CEREBRAL METABOLISM; NEGATIVE SYMPTOMS; PET; PERFUSION; NUCLEUS; MRI; PERFORMANCE; ATTENTION; DISORDER;
Keywords:
positron emission tomography (PET) deoxyglucose; occipital cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Danos, P Univ Magdeburg, Dept Psychiat, Leipziger Str 44, D-39120 Magdeburg, Germany Univ Magdeburg Leipziger Str 44 Magdeburg Germany D-39120 ermany
Citazione:
P. Danos et al., "EEG alpha rhythm and glucose metabolic rate in the thalamus in schizophrenia", NEUROPSYCHB, 43(4), 2001, pp. 265-272

Abstract

Positron emission tomography with uptake of [F-18]fluo- rodeoxyglucose (FDG) and quantitative EEG were simultaneously performed in 18 medication-freepatients with schizophrenia and in 13 normal volunteers. Subjects performed the Continuous Performance Task (CPT) during FDG uptake. Correlations were calculated between alpha power during the CPT and glucose metabolic rate (GMR) in thalamic regions and between alpha power during the CPT and GMR inoccipital cortices. Regression analyses were used to describe the prediction of GMR in the occipital cortices and in the thalamic regions of occipital alpha power. In normal controls, we found (1) significant negative correlations between absolute alpha power and GMR in the left occipital cortex, (2) significant positive correlations between normalized alpha power and GMRin the right and left lateral thalamus and (3) combined effects of GMR in the thalamic regions and the occipital cortices on alpha power, which accounted for 98% of the variance of alpha power. In patients with schizophrenia, we found no significant correlations between alpha power and GMR in the occipital cortices or between alpha power and GMR in the thalamic regions. Correlation coefficients between absolute alpha power and GMR in the left occipital cortex and between normalized alpha power and GMR in the left lateral thalamus were significantly different in normal subjects compared to schizophrenic patients. The present findings provide evidence for involvement of the thalamus in the generation of alpha rhythm in humans. Furthermore, the present results suggest differences in thalamocortical circuits between normal controls and schizophrenic subjects. Copyright (C) 2001 S.Karger AG,Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:35:25