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Titolo:
Differential effects of age on brain gray matter in bipolar patients and healthy individuals
Autore:
Brambilla, P; Harenski, K; Nicoletti, M; Mallinger, AG; Frank, E; Kupfer, DJ; Keshavan, MS; Soares, JC;
Indirizzi:
Univ Pittsburgh, Sch Med, Western Psychiat Inst & Clin, Neurochem Brain Imaging Lab,Dept Psychiat, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 sychiat, Pittsburgh, PA 15213 USA Univ Pittsburgh, Dept Pharmacol, Sch Med, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 Sch Med, Pittsburgh, PA 15260 USA Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 Psychol, Pittsburgh, PA 15260 USA Univ Pittsburgh, Dept Neurosci, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 eurosci, Pittsburgh, PA 15260 USA Univ Pavia, Sch Med, IRCCS S Matteo, Dept Psychiat, I-27100 Pavia, Italy Univ Pavia Pavia Italy I-27100 tteo, Dept Psychiat, I-27100 Pavia, Italy
Titolo Testata:
NEUROPSYCHOBIOLOGY
fascicolo: 4, volume: 43, anno: 2001,
pagine: 242 - 247
SICI:
0302-282X(2001)43:4<242:DEOAOB>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBCORTICAL SIGNAL HYPERINTENSITIES; QUANTITATIVE CEREBRAL ANATOMY; MAGNETIC-RESONANCE; WHITE-MATTER; AFFECTIVE-DISORDERS; MOOD DISORDERS; MRI; ABNORMALITIES; LESIONS; DEPRESSION;
Keywords:
neuroimaging; aging; affective disorders; mood disorders; magnetic resonance imaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Soares, JC Univ Pittsburgh, Sch Med, Western Psychiat Inst & Clin, Neurochem Brain Imaging Lab,Dept Psychiat, 3811 OHara St, Pittsburgh, PA 15213 USAUniv Pittsburgh 3811 OHara St Pittsburgh PA USA 15213 15213 USA
Citazione:
P. Brambilla et al., "Differential effects of age on brain gray matter in bipolar patients and healthy individuals", NEUROPSYCHB, 43(4), 2001, pp. 242-247

Abstract

This study examined possible differences in total gray and white matter brain content in bipolar patients and healthy individuals, and their relationship with age. 22 DSM-IV bipolar patients and 22 healthy controls underwenta 1.5-tesla Spoiled Gradient Recalled Acquisition (SPGR) MRI. Evaluators blind to patients' identities measured total brain, gray and white matter volumes using a semi-automated software. No differences were found for total brain volume, gray matter or white matter volumes between bipolar patients and healthy controls (MAN-COVA, age as covariate, p > 0.05). Age was inversely correlated with total gray matter volume in patients (r = -0.576, p = 0.005), but not in controls (r = -0.193, p = 0.388), Our findings suggest that any existing gray matter deficits in bipolar disorder are likely to be localized to specific brain regions, rather than generalized. The inverse correlation between age and brain gray matter volumes in bipolar patients, not present in healthy controls, in this sample of mostly middle-aged adults,could possibly indicate more pronounced age-related gray matter decline inbipolar patients, and may be of potential relevance for the pathophysiology of the disorder. Copyright (C) 2001S.KargerAG,Basel.

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Documento generato il 22/01/20 alle ore 13:02:40