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Titolo:
Excess tryptophan hydroxylase 17 779C allele in surviving cotwins of monozygotic twin suicide victims
Autore:
Roy, A; Rylander, G; Forslund, K; Asberg, M; Mazzanti, CM; Goldman, D; Nielsen, DA;
Indirizzi:
New Jersey Hlth Care Syst, Dept Vet Affairs, Psychiat Serv 116A, E Orange,NJ 07019 USA New Jersey Hlth Care Syst E Orange NJ USA 07019 6A, E Orange,NJ 07019 USA NIAAA, Neurogenet Lab, Bethesda, MD USA NIAAA Bethesda MD USANIAAA, Neurogenet Lab, Bethesda, MD USA Karolinska Hosp, Dept Clin Neurosci, Stockholm, Sweden Karolinska Hosp Stockholm Sweden Dept Clin Neurosci, Stockholm, Sweden
Titolo Testata:
NEUROPSYCHOBIOLOGY
fascicolo: 4, volume: 43, anno: 2001,
pagine: 233 - 236
SICI:
0302-282X(2001)43:4<233:ETH17A>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN TRANSPORTER GENE; MANIC-DEPRESSIVE ILLNESS; AFFECTIVE-DISORDERS; RECEPTOR GENE; POLYMORPHISM; ASSOCIATION; AGGRESSION; FREQUENCY; PROMOTER; BEHAVIOR;
Keywords:
serotonin; genetics; suicide; twins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Roy, A New Jersey Hlth Care Syst, Dept Vet Affairs, Psychiat Serv 116A, 385 Tremont & S Ctr St, E Orange, NJ 07019 USA New Jersey Hlth Care Syst 385 Tremont & S Ctr St E Orange NJ USA 07019
Citazione:
A. Roy et al., "Excess tryptophan hydroxylase 17 779C allele in surviving cotwins of monozygotic twin suicide victims", NEUROPSYCHB, 43(4), 2001, pp. 233-236

Abstract

Objective: To evaluate the relationship of the tryptophan hydroxylase (TPH) genotype to suicidality by the study of surviving monozygotic (MZ) cotwins of twins who committed suicide, Method: Twenty-four surviving Swedish MZ twins whose MZ cotwins had committed suicide were compared to 158 demographically sampled Swedish general population controls for TPH alleles, We alsoexamined serotonin transporter alleles, Results: The living MZ cotwins of suicide victims had a significantly higher TPH 17 779C allele frequency than controls, No significant difference was observed for serotonin transporter alleles, Conclusion: These results, in a small sample, suggest the possibility that the 17 779C allele of the TPH gene may be associated with an increased risk of suicide, further studies in larger samples are needed, Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 10:10:49