Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
2-Chloro-N-6-cyclopentyladenosine-elicited attenuation of evoked glutamaterelease is not sufficient to give complete protection against pilocarpine-induced seizures in rats
Autore:
Khan, GM; Smolders, I; Ebinger, G; Michotte, Y;
Indirizzi:
Free Univ Brussels, Dept Pharmaceut Chem & Drug Anal, B-1090 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1090 nal, B-1090 Brussels, Belgium Free Univ Brussels, Dept Neurol, B-1090 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1090 rol, B-1090 Brussels, Belgium
Titolo Testata:
NEUROPHARMACOLOGY
fascicolo: 5, volume: 40, anno: 2001,
pagine: 657 - 667
SICI:
0028-3908(200104)40:5<657:2AOEG>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREELY MOVING RATS; ADENOSINE RECEPTORS; HIPPOCAMPAL SLICES; STRIATAL DOPAMINE; NERVE-TERMINALS; AMINO-ACIDS; 2-CHLOROADENOSINE; A1; MODULATION; A(1);
Keywords:
2-chloro-N-6-cyclopentyladenosine; 8-cyclopentyl-1,3-dipropylxanthine pilocarpine-induced seizures; glutamate; GABA; dopamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Michotte, Y Free Univ Brussels, Dept Pharmaceut Chem & Drug Anal, Laarbeeklaan 103, B-1090 Brussels, Belgium Free Univ Brussels Laarbeeklaan 103 Brussels Belgium B-1090 m
Citazione:
G.M. Khan et al., "2-Chloro-N-6-cyclopentyladenosine-elicited attenuation of evoked glutamaterelease is not sufficient to give complete protection against pilocarpine-induced seizures in rats", NEUROPHARM, 40(5), 2001, pp. 657-667

Abstract

The effects of 2-chloro-N-6-cyclopentyladenosine (CCPA) perfused intrahippocampally (1 muM) and injected intraperitoneally (0.5 mg/kg) were investigated in focally-evoked pilocarpine-induced (10 mM) seizures in freely movingrats. While the intrahippocampal perfusion of this highly selective adenosine A(1) receptor agonist gave complete protection against pilocarpine-induced seizures, systemic administration only partially protected the animals,as evaluated by concomitant behavioural and electrocorticographical (ECoG)observations and monitoring of the neurotransmitter alterations. However, pilocarpine-evoked elevation of hippocampal glutamate overflow was significantly attenuated by CCPA irrespective of the mode of administration. Acute pretreatment with systemic 8-cyclopentyl-1,3-dipropylxanthine,a selective A(1) antagonist, reversed both the partial protective effect and the attenuating effect on the extracellular glutamate elicited by systemic CCPA administration. Intrahippocampal CCPA markedly reduced basal hippocampal dopamineefflux but not GABA or glutamate and considerably attenuated the pilocarpine-evoked elevation in dopamine levels. Systemic CCPA appeared to have little influence on the overall pattern of dopamine elevation. The findings give evidence that CCPA-elicited abatement of the evoked glutamate release alone, cannot fully account for its anticonvulsant effect and may suggest thatthe effects mediated by adenosine on postsynaptic adenosine receptors could be more crucial for its anticonvulsant effect. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 15:46:41