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Titolo:
Low leptin levels but normal body mass indices in patients with depressionor schizophrenia
Autore:
Kraus, T; Haack, M; Schuld, A; Hinze-Selch, D; Pollmacher, T;
Indirizzi:
Max Planck Inst Psychiat, D-80804 Munich, Germany Max Planck Inst Psychiat Munich Germany D-80804 D-80804 Munich, Germany
Titolo Testata:
NEUROENDOCRINOLOGY
fascicolo: 4, volume: 73, anno: 2001,
pagine: 243 - 247
SICI:
0028-3835(200104)73:4<243:LLLBNB>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA LEPTIN; ANOREXIA-NERVOSA; WEIGHT-GAIN; HORMONE; HUMANS; BRAIN; ANTIDEPRESSANTS; SECRETION; RECEPTORS; OBESITY;
Keywords:
leptin; body mass index; psychiatric disorders; depression; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Pollmacher, T Max Planck Inst Psychiat, Kraepelinstr 10, D-80804 Munich, Germany Max Planck Inst Psychiat Kraepelinstr 10 Munich Germany D-80804
Citazione:
T. Kraus et al., "Low leptin levels but normal body mass indices in patients with depressionor schizophrenia", NEUROENDOCR, 73(4), 2001, pp. 243-247

Abstract

Appetite, food intake and weight are frequently altered in psychiatric disorders such as major depression and schizophrenia. The few studies investigating weight and the body mass index (BMI) have yielded variable results, Leptin, a fat cell-derived hormone signalling to the brain the size of the adipose tissue, plays a pivotal role in the regulation of weight and food intake. Moreover, leptin is involved in the control of other behaviors and inbrain development. There is almost no information about the amounts of circulating leptin in major depression or schizophrenia. We investigated the BMI and plasma leptin levels in patients with major depression (n = 62), schizophrenia (n = 42), and in healthy controls (n = 64). Mean BMIs did not differ between groups. However, leptin levels were significantly lower in both patient groups compared to healthy controls. Moreover, patients sufferingfrom schizophrenia showed significantly lower leptin levels than depressedpatients. Decreased leptin levels were independent of psychotropic medication, We conclude that depression and schizophrenia go along with decreased systemic leptin concentrations that cannot be explained by medication or analtered BMI. Hence, leptin might play an important pathophysiological rolein these psychiatric disorders that deserves further scientific attention. Copyright (C) 2001 S. Karger AG. Basel.

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Documento generato il 21/01/20 alle ore 00:52:33