Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Experimental models of Parkinson's disease
Autore:
Beal, MF;
Indirizzi:
New York Hosp, Cornell Med Ctr, Dept Neurol, New York, NY 10021 USA New York Hosp New York NY USA 10021 , Dept Neurol, New York, NY 10021 USA
Titolo Testata:
NATURE REVIEWS NEUROSCIENCE
fascicolo: 5, volume: 2, anno: 2001,
pagine: 325 - 332
SICI:
1471-0048(200105)2:5<325:EMOPD>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; MPTP-INDUCED PARKINSONISM; INDUCED DOPAMINE DEPLETION; NEURONS IN-VIVO; SUBSTANTIA-NIGRA; ALPHA-SYNUCLEIN; SUPEROXIDE-DISMUTASE; TRANSGENIC MICE; SUBTHALAMIC NUCLEUS; OXIDATIVE STRESS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
105
Recensione:
Indirizzi per estratti:
Indirizzo: Beal, MF New York Hosp, Cornell Med Ctr, Dept Neurol, 525 E 68th St, New York, NY 10021 USA New York Hosp 525 E 68th St New York NY USA 10021 k, NY 10021 USA
Citazione:
M.F. Beal, "Experimental models of Parkinson's disease", NAT REV NEU, 2(5), 2001, pp. 325-332

Abstract

Research into the pathogenesis of Parkinson's disease has been rapidly advanced by the development of animal models. Initial models were developed byusing toxins that specifically targeted dopamine neurons, the most successful of which used 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, a toxin that causes parkinsonism in man. More recently, the identification of alpha -synuclein mutations as a rare cause of Parkinson's disease has led to the development of alpha -synuclein transgenic mice and Drosophila. Here, I discuss the merits and limitations of these different animal models in our attempts to understand the physiology of Parkinson's disease and to develop new therapies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 22:40:00