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Titolo:
Role of AMPA receptor endocytosis in synaptic plasticity
Autore:
Carroll, RC; Beattie, EC; von Zastrow, M; Malenka, RC;
Indirizzi:
Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA Albert Einstein Coll Med Bronx NY USA 10461 Neurosci, Bronx, NY 10461 USA Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA94143 USA Univ Calif San Francisco San Francisco CA USA 94143 rancisco, CA94143 USA Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Nancy Pritzker Lab, Palo Alto, CA 94304 USA Stanford Univ Palo Alto CA USA 94304 ritzker Lab, Palo Alto, CA 94304 USA
Titolo Testata:
NATURE REVIEWS NEUROSCIENCE
fascicolo: 5, volume: 2, anno: 2001,
pagine: 315 - 324
SICI:
1471-0048(200105)2:5<315:ROAREI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM DEPRESSION; IONOTROPIC GLUTAMATE RECEPTORS; CLATHRIN-MEDIATED ENDOCYTOSIS; DOMAIN-CONTAINING PROTEINS; SILENT SYNAPSES; HIPPOCAMPAL-NEURONS; BENZODIAZEPINE RECEPTORS; DEPENDENT ENDOCYTOSIS; SURFACE EXPRESSION; COUPLED RECEPTORS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
95
Recensione:
Indirizzi per estratti:
Indirizzo: Malenka, RC Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA Albert Einstein Coll Med Bronx NY USA 10461 onx, NY 10461 USA
Citazione:
R.C. Carroll et al., "Role of AMPA receptor endocytosis in synaptic plasticity", NAT REV NEU, 2(5), 2001, pp. 315-324

Abstract

Activity-mediated changes in the strength of synaptic communication are important for the establishment of proper neuronal connections during development and for the experience-dependent modification of neural circuitry thatis believed to underlie all forms of behavioural plasticity. Owing to the wide-ranging significance of synaptic plasticity, considerable efforts havebeen made to identify the mechanisms by which synaptic changes are triggered and expressed. New evidence indicates that one important expression mechanism of several long-lasting forms of synaptic plasticity might involve the physical transport of AMPA-type glutamate receptors in and out of the synaptic membrane. Here, we focus on the rapidly accumulating evidence that AMPA receptors undergo regulated endocytosis, which is important for long-term depression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:10:02