Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Trp2 regulates entry of Ca2(+) into mouse sperm triggered by egg ZP3
Autore:
Jungnickel, MK; Marrero, H; Birnbaumer, L; Lemos, JR; Florman, HM;
Indirizzi:
Univ Massachusetts, Sch Med, Dept Cell Biol, Worcester, MA 01655 USA Univ Massachusetts Worcester MA USA 01655 l Biol, Worcester, MA 01655 USA Univ Massachusetts, Sch Med, Dept Physiol, Worcester, MA 01655 USA Univ Massachusetts Worcester MA USA 01655 hysiol, Worcester, MA 01655 USA Univ Calif Los Angeles, Sch Med, Dept Anesthesiol, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA
Titolo Testata:
NATURE CELL BIOLOGY
fascicolo: 5, volume: 3, anno: 2001,
pagine: 499 - 502
SICI:
1465-7392(200105)3:5<499:TREOCI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; CAPACITATIVE CA2+ ENTRY; ACROSOME REACTION; MAMMALIAN SPERM; STORE DEPLETION; CALCIUM INFLUX; CHANNELS; THAPSIGARGIN; CELLS; GLYCOPROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Jungnickel, MK Univ Massachusetts, Sch Med, Dept Cell Biol, Worcester, MA 01655 USA Univ Massachusetts Worcester MA USA 01655 er, MA 01655 USA
Citazione:
M.K. Jungnickel et al., "Trp2 regulates entry of Ca2(+) into mouse sperm triggered by egg ZP3", NAT CELL BI, 3(5), 2001, pp. 499-502

Abstract

In many cells, receptor activation initiates sustained Ca2+ entry which iscritical in signal transduction(1). Mammalian transient receptor potential(Trp) proteins, which are homologous to the Drosophila photoreceptor-cell Trp protein, have emerged as candidate subunits of the ion channels that mediate this influx. As a consequence of over-expression, these proteins produce cation currents that open either after depletion of internal Ca2+ stoves or through receptor activation(2). However, determining the role of endogenous Trp proteins in signal transduction is complicated by the absence of selective antagonists. Here we examine Trp function during sperm-egg interaction, The sperm acrosome reaction is a Ca2+-dependent secretary event thatmust be completed before fertilization. in mammals, exocytosis is triggered during gamete contact by ZP3, a glycoprotein constituent of the egg's extracellular matrix, or zona pellucida (ZP). ZP3 activates trimeric G proteins and phospholipase C and causes a transient Ca2+ influx into sperm throughT-type Ca2+ channels(3). These early responses promote a second Ca2+-entrypathway, thereby producing sustained increases in intracellular Ca2+ concentration ([Ca2+](i)) that drive acrosome reactions(4). Our results show that Trp2 is essential for the activation of sustained Ca2+ influx into sperm by ZP3.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 08:48:31