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Titolo:
Stabilization of p53 by p14(ARF) without relocation of MDM2 to the nucleolus
Autore:
Llanos, S; Clark, PA; Rowe, J; Peters, G;
Indirizzi:
Imperial Canc Res Fund, London WC2A 3PX, England Imperial Canc Res Fund London England WC2A 3PX London WC2A 3PX, England
Titolo Testata:
NATURE CELL BIOLOGY
fascicolo: 5, volume: 3, anno: 2001,
pagine: 445 - 452
SICI:
1465-7392(200105)3:5<445:SOPBPW>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLIN-DEPENDENT KINASES; TUMOR-SUPPRESSOR; NUCLEAR EXPORT; ALTERNATIVE PRODUCT; LOCALIZATION; P19(ARF); DEGRADATION; PROTEINS; LOCUS; RB;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Llanos, S Imperial Canc Res Fund, 44 Lincolns Inn Fields, London WC2A 3PX,England Imperial Canc Res Fund 44 Lincolns Inn Fields London England WC2A3PX
Citazione:
S. Llanos et al., "Stabilization of p53 by p14(ARF) without relocation of MDM2 to the nucleolus", NAT CELL BI, 3(5), 2001, pp. 445-452

Abstract

The alternative product of the human INK4a/ARF locus, p14(ARF), has the potential to act as a tumour suppressor by binding to and inhibiting the p53 antagonist MDM2. Current models propose that ARF function depends on its ability to sequester MDM2 in the nucleolus. Here we describe situations in which stabilization of MDM2 and p53 occur without relocalization of endogenous MDM2 from the nucleoplasm. Conversely, forms of Apr that do not accumulate in the nucleolus retain the capacity to stabilize MDM2 and p53. We therefore propose that nucleolar localization is not essential for ARF function but may enhance the availability of ARF to inhibit MDM2.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 11:50:34