Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Coping with the inevitable: how cells repair a torn surface membrane
Autore:
McNeil, PL; Terasaki, M;
Indirizzi:
Med Coll Georgia, Dept Cellular Biol, Augusta, GA 30912 USA Med Coll Georgia Augusta GA USA 30912 ellular Biol, Augusta, GA 30912 USA Med Coll Georgia, Inst Mol Med & Genet, Augusta, GA 30912 USA Med Coll Georgia Augusta GA USA 30912 Med & Genet, Augusta, GA 30912 USA Univ Connecticut, Ctr Hlth, Dept Physiol, Farmington, CT 06032 USA Univ Connecticut Farmington CT USA 06032 hysiol, Farmington, CT 06032 USA
Titolo Testata:
NATURE CELL BIOLOGY
fascicolo: 5, volume: 3, anno: 2001,
pagine: E124 - E129
SICI:
1465-7392(200105)3:5<E124:CWTIHC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST GROWTH-FACTOR; PLASMA-MEMBRANE; INTERMEDIATE FILAMENTS; PROTEOLYTIC ACTIVITY; MECHANICAL-STRESS; ENDOTHELIAL-CELLS; CONE FORMATION; IN-VIVO; FUSION; EXOCYTOSIS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: McNeil, PL Med Coll Georgia, Dept Cellular Biol, Augusta, GA 30912 USA MedColl Georgia Augusta GA USA 30912 l, Augusta, GA 30912 USA
Citazione:
P.L. McNeil e M. Terasaki, "Coping with the inevitable: how cells repair a torn surface membrane", NAT CELL BI, 3(5), 2001, pp. E124-E129

Abstract

Disruption of the cell plasma membrane is a commonplace occurrence in manymechanically challenging, biological environments. 'Resealing' is the emergency response required for cell survival. Resealing is triggered by Ca2+ entering through the disruption; this causes vesicles present in cytoplasm underlying the disruption site to fuse rapidly with one another (homotypically) and also with the adjacent plasma membrane (heterotypically/exocytotically). The large vesicular products of homotypic fusion are added as a reparative 'patch' across the disruption, when its resealing requires membrane replacement. The simultaneous activation of the local cytoskeleton supports these membrane fusion events. Resealing is clearly a complex and dynamic cell adaptation, and, as we emphasize here, may be an evolutionarily primitive one that arose shortly after the ancestral eukaryote lost its protective cell wall.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 02:39:08