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Titolo:
Mutations induced by 5-formyl-2 '-deoxyuridine in Escherichia coli includebase substitutions that can arise from mispairs of 5-formyluracil with guanine, cytosine and thymine
Autore:
Anensen, H; Provan, F; Lian, AT; Reinertsen, SHHS; Ueno, Y; Matsuda, A; Seeberg, E; Bjelland, S;
Indirizzi:
Stavanger Univ Coll, Sch Sci & Technol, N-4091 Stavanger, Norway StavangerUniv Coll Stavanger Norway N-4091 ol, N-4091 Stavanger, Norway Hokkaido Univ, Grad Sch Pharmaceut Sci, Kita Ku, Sapporo, Hokkaido 0600812, Japan Hokkaido Univ Sapporo Hokkaido Japan 0600812 oro, Hokkaido 0600812, Japan Univ Oslo, Natl Hosp, Inst Med Microbiol, Dept Mol Biol, N-0027 Oslo, Norway Univ Oslo Oslo Norway N-0027 crobiol, Dept Mol Biol, N-0027 Oslo, Norway
Titolo Testata:
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
fascicolo: 1-2, volume: 476, anno: 2001,
pagine: 99 - 107
SICI:
1386-1964(20010509)476:1-2<99:MIB5'I>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA DAMAGE; IONIZING-RADIATION; OXIDATIVE DAMAGE; 8-HYDROXYGUANINE 7,8-DIHYDRO-8-OXOGUANINE; ENZYMATIC REPAIR; MEDIATED DAMAGE; EXCISION-REPAIR; STRAIN TA102; IN-VITRO; MUTAGENESIS;
Keywords:
oxidative DNA damage; oxidized nucleotide DNA precursor; 5-formyluracil; 5-formyl-2 '-deoxyuridine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Bjelland, S Stavanger Univ Coll, Sch Sci & Technol, POB 2557, N-4091 Stavanger, Norway Stavanger Univ Coll POB 2557 Stavanger Norway N-4091 , Norway
Citazione:
H. Anensen et al., "Mutations induced by 5-formyl-2 '-deoxyuridine in Escherichia coli includebase substitutions that can arise from mispairs of 5-formyluracil with guanine, cytosine and thymine", MUT RES-F M, 476(1-2), 2001, pp. 99-107

Abstract

5-Formyluracil (5-foU) is a major oxidation product of thymine formed in yields comparable to that of 8-oxoguanine in DNA by ionizing radiation. Whereas the mutagenic effects of 8-oxoguanine are well understood, the investigation of the biological implications of 5-foU has so far been limited. Herewe demonstrate that 5-formyl-2 ' -deoxyuridine (5-fodUrd) supplied to the growth medium of Escherichia coli induces several base substitutions at different frequencies at position 461 in the lacZ gene in the following order:A . T --> G . C > G . C --> A . T > G . C --> T . A much greater than A . T --> T . A > A . T --> C . G. No induction of G C -, C G transversions wasobserved. It is inferred that 5-fodUrd will be incorporated into the DNA during cell growth, forming mispairs with guanine, cytosine and thymine during replication. It, thus, appears that cell growth in the presence of 5-fodUrd may represent a good model for elucidating the cellular effects of 5-foU residues in DNA. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 29/03/20 alle ore 23:56:12