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Titolo:
Recent molecular advances in studies of the concentrative Na+-dependent nucleoside transporter (CNT) family: identification and characterization of novel human and mouse proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib)
Autore:
Ritzel, MWL; Ng, AML; Yao, SYM; Graham, K; Loewen, SK; Smith, KM; Hyde, RJ; Karpinski, E; Cass, CE; Baldwin, SA; Young, JD;
Indirizzi:
Univ Alberta, Dept Physiol, Membrane Transport Res Grp, Edmonton, AB T6G 2H7, Canada Univ Alberta Edmonton AB Canada T6G 2H7 Grp, Edmonton, AB T6G 2H7, Canada Univ Alberta, Dept Oncol, Membrane Transport Res Grp, Edmonton, AB T6G 2H7, Canada Univ Alberta Edmonton AB Canada T6G 2H7 Grp, Edmonton, AB T6G 2H7, Canada Univ Leeds, Sch Biochem & Mol Biol, Leeds LS2 9JT, W Yorkshire, England Univ Leeds Leeds W Yorkshire England LS2 9JT S2 9JT, W Yorkshire, England
Titolo Testata:
MOLECULAR MEMBRANE BIOLOGY
fascicolo: 1, volume: 18, anno: 2001,
pagine: 65 - 72
SICI:
0968-7688(200101/05)18:1<65:RMAISO>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
NA+/GLUCOSE COTRANSPORTER SGLT2; XENOPUS-LAEVIS OOCYTES; FUNCTIONAL EXPRESSION; SODIUM/NUCLEOSIDE COTRANSPORTERS; HL-60 CELLS; CLONING; EI; DIFFERENTIATION; ADENOSINE; MECHANISM;
Keywords:
nucleoside transport; nucleoside drugs; human CNT3; mouse CNT3; system cib;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Young, JD Univ Alberta, Dept Physiol, Membrane Transport Res Grp, Edmonton, AB T6G 2H7, Canada Univ Alberta Edmonton AB Canada T6G 2H7 ton, AB T6G 2H7, Canada
Citazione:
M.W.L. Ritzel et al., "Recent molecular advances in studies of the concentrative Na+-dependent nucleoside transporter (CNT) family: identification and characterization of novel human and mouse proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib)", MOL MEMBR B, 18(1), 2001, pp. 65-72

Abstract

The human concentrative (Na+-linked) plasma membrane transport proteins hCNT1 and hCNT2, found primarily in specialized epithelia, are selective for pyrimidine nucleosides (system cit) and purine nucleosides (system cif), respectively. Both have orthologs in other mammalian species and belong to a gene family (CNT) that also includes members in lower vertebrates, insects,nematodes, pathogenic yeast and bacteria. The CNT transporter family also includes a newly identified human and mouse CNT3 transporter isoform. This paper reviews the studies of CNT transport proteins that led to the identification of hCNT3 and mCNT3, and gives an overview of the structural and functional properties of these latest CNT family members. hCNT3 and mCNT3 haveprimary structures that place them in a CNT subfamily separate from CNT1/2, transport a wide range of physiological pyrimidine and purine nucleosidesand antineoplastic and antiviral nucleoside drugs (system cib), and exhibit a Na+:uridine coupling ratio of at least 2:1 (cf 1:1 for hCNT1/2). Cells and tissues containing hCNT3 transcripts include mammary gland, differentiated HL-60 cells, pancreas, bone marrow, trachea, liver, prostrate and regions of intestine, brain and heart. In HL-60 cells, hCNT3 is transcriptionally regulated by phorbol myristate (PMA). The hCNT3 gene, which contains an upstream PMA response element, mapped to 9q22.2 (cf chromosome 15 for hCNT1 and hCNT2).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:57:51