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Titolo:
The role of system A for neutral amino acid transport in the regulation ofcell volume
Autore:
Bussolati, O; DallAsta, V; Franchi-Gazzola, R; Sala, R; Rotoli, BM; Visigalli, R; Casado, J; Lopez-Fontanals, M; Pastor-Anglada, M; Gazzola, GC;
Indirizzi:
Univ Parma, Dept Expt Med, Unit Gen & Clin Pathol, I-43100 Parma, Italy Univ Parma Parma Italy I-43100 t Gen & Clin Pathol, I-43100 Parma, Italy Univ Barcelona, Dept Biochem & Mol Biol, E-08028 Barcelona, Spain Univ Barcelona Barcelona Spain E-08028 ol Biol, E-08028 Barcelona, Spain
Titolo Testata:
MOLECULAR MEMBRANE BIOLOGY
fascicolo: 1, volume: 18, anno: 2001,
pagine: 27 - 38
SICI:
0968-7688(200101/05)18:1<27:TROSAF>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CULTURED HUMAN-FIBROBLASTS; HAMSTER OVARY CELLS; ISOLATED RAT HEPATOCYTES; HUMAN PLACENTAL TROPHOBLAST; VASCULAR ENDOTHELIAL-CELLS; TISSUE EXPRESSION PATTERN; STRESSED MAMMALIAN-CELLS; ANTI-INFLAMMATORY DRUGS; HUMAN SYNOVIAL-CELLS; SMOOTH-MUSCLE CELLS;
Keywords:
cell volume; stress; amino acids; transport; glutamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
149
Recensione:
Indirizzi per estratti:
Indirizzo: Bussolati, O Univ Parma, Dept Expt Med, Unit Gen & Clin Pathol, Via Volturno 39, I-43100 Parma, Italy Univ Parma Via Volturno 39 Parma Italy I-43100 Parma, Italy
Citazione:
O. Bussolati et al., "The role of system A for neutral amino acid transport in the regulation ofcell volume", MOL MEMBR B, 18(1), 2001, pp. 27-38

Abstract

System A is a secondary active, sodium dependent transport system for neutral amino acids. Strictly coupled with Na, K-ATPase, its activity determines the size of the intracellular amino acid pool, through a complex network of metabolic reaction and exchange fluxes. Many hormones and drugs affect system A activity in specific cell models or tissues. In all the cell modelstested thus far the activity of the system is stimulated by amino acid starvation, cell cycle progression, and the incubation under hypertonic conditions. These three conditions produce marked alterations of cell volume. Thestimulation of system A activity plays an important role in cell volume restoration, through an expansion of the intracellular amino acid pool. Undernormal conditions, system A substrates represent a major fraction of cell compatible osmolytes, organic compounds that exert a protein stabilizing effect. It is, therefore, likely that the activation of system A represents aportion of a more complex response triggered by exposure to stresses of various nature. Since system A transporters have been recently cloned, the molecular bases of these regulatory mechanisms will probably be elucidated ina short time.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 18:19:15