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Titolo:
Increased concentrations of cathepsin D in peritoneal fluid from women with endometriosis
Autore:
Suzumori, N; Ozaki, Y; Ogasawara, M; Suzumori, K;
Indirizzi:
Baylor Coll Med, Dept Pathol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 , Dept Pathol, Houston, TX 77030 USA Nagoya City Univ, Sch Med, Dept Obstet & Gynecol, Nagoya, Aichi 467, JapanNagoya City Univ Nagoya Aichi Japan 467 Gynecol, Nagoya, Aichi 467, Japan Univ Gothenburg, Inst Physiol & Pharmacol, Perinatal Ctr, Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden ol, Perinatal Ctr, Gothenburg, Sweden
Titolo Testata:
MOLECULAR HUMAN REPRODUCTION
fascicolo: 5, volume: 7, anno: 2001,
pagine: 459 - 462
SICI:
1360-9947(200105)7:5<459:ICOCDI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
BREAST-CANCER; MENSTRUAL-CYCLE; GROWTH-FACTORS; SERUM; PROGESTERONE; EXPRESSION; CELLS; CARCINOMA; ESTROGEN; SURGERY;
Keywords:
cathepsin D; endometriosis; gonadotrophin-releasing hormone; peritoneal fluid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Suzumori, N Baylor Coll Med, Dept Pathol, 1 Baylor Plaza S217, Houston, TX77030 USA Baylor Coll Med 1 Baylor Plaza S217 Houston TX USA 77030 0 USA
Citazione:
N. Suzumori et al., "Increased concentrations of cathepsin D in peritoneal fluid from women with endometriosis", MOL HUM REP, 7(5), 2001, pp. 459-462

Abstract

To assess the release of the proteolytic enzyme cathepsin D in endometriosis, concentrations in peritoneal fluid and serum were measured by ELISA in 54 women with (n = 33) and without (n = 21) endometriosis, Surgery was scheduled in either the proliferative or secretory phase of the menstrual cycle. The concentrations of cathepsin D in the peritoneal fluid were markedly elevated in the endometriosis patients (median 58 ng/ml, interquartile range0-166 ng/ml) as compared to the controls (5 ng/ml, 0-86 ng/ml), especiallyin women with late stage disease (It = 19, stages III/IV) and in those notundergoing gonadotrophin-releasing hormone (GnRH) agonist therapy (n = 15), No significant difference was determined in cathepsin D concentrations ofthe serum from women with and without endometriosis, We conclude that cathepsin D is an important factor that may contribute to the pathogenesis of endometriosis, possibly by promoting digestion of extracellular matrix proteins. These results have implications for the therapeutic efficacy of GnRH agonists.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 14:00:48