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Titolo:
Expression of epithelial neutrophil-activating peptide 78 in cultured human endometrial stromal cells
Autore:
Nasu, K; Arima, K; Kai, K; Fujisawa, K; Nishida, M; Miyakawa, I;
Indirizzi:
Oita Med Univ, Dept Obstet & Gynecol, Hasama, Oita 8795593, Japan Oita MedUniv Hasama Oita Japan 8795593 ecol, Hasama, Oita 8795593, Japan
Titolo Testata:
MOLECULAR HUMAN REPRODUCTION
fascicolo: 5, volume: 7, anno: 2001,
pagine: 453 - 458
SICI:
1360-9947(200105)7:5<453:EOENP7>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR-BINDING; INFLAMMATORY CYTOKINES; CHEMOKINE ENA-78; GENE-EXPRESSION; INTERLEUKIN-8; DISEASE; FAMILY; CXC; RESIDUES; BIOLOGY;
Keywords:
cytokines; chemokines; ENA-78; endometrial stromal cell; progesterone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Nasu, K Oita Med Univ, Dept Obstet & Gynecol, Hasama, Oita 8795593, Japan Oita Med Univ Hasama Oita Japan 8795593 sama, Oita 8795593, Japan
Citazione:
K. Nasu et al., "Expression of epithelial neutrophil-activating peptide 78 in cultured human endometrial stromal cells", MOL HUM REP, 7(5), 2001, pp. 453-458

Abstract

It has been demonstrated that human endometrial stromal cells (ESC) produce a variety of chemokines in vivo and in vitro, To evaluate the expression of epithelial neutrophil-activating peptide 78 (ENA-78) in the endometrium,concentrations of ENA-78 in cyclic endometrial tissues were measured usingenzyme-linked immunosorbent assay. The expression of ENA-78 was also detected in cyclic endometrium by immunohistochemistry. Endometrial tissues in the secretory phase contained higher amounts of ENA-78 protein than did those in the proliferative phase. Immunofluorescence staining revealed that ENA-78 protein was localized mainly in the stroma of endometrium. In addition,to evaluate the involvement of inflammatory mediators and ovarian steroid hormones in the production of ENA-78 by ESC was evaluated by in-vitro studies. Unstimulated ESC constitutively secreted ENA-78. Progesterone, lipopolysaccharide, tumour necrosis factor-a, and interleukin-1 beta significantly stimulated the expression of ENA-78 by ESC. It is suggested that the production of ENA-78 by ESC is regulated by progesterone as well as by the inflammatory mediators. The modulation of ENA-78 concentration in the local environment by these mediators may contribute to the normal and pathological processes of human reproduction through regulation of leukocyte trafficking into the endometrium.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:38:00