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Titolo:
Hydroxysteroid dehydrogenases: ancient and modern regulators of adrenal and sex steroid action
Autore:
Baker, ME;
Indirizzi:
Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 pt Med, La Jolla, CA 92093 USA
Titolo Testata:
MOLECULAR AND CELLULAR ENDOCRINOLOGY
fascicolo: 1-2, volume: 175, anno: 2001,
pagine: 1 - 4
SICI:
0303-7207(20010425)175:1-2<1:HDAAMR>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
EEL ANGUILLA-JAPONICA; 11-BETA-HYDROXYSTEROID DEHYDROGENASE; 17-BETA-HYDROXYSTEROID DEHYDROGENASES; MINERALOCORTICOID RECEPTOR; GLUCOCORTICOID RECEPTOR; RETINOL DEHYDROGENASES; BINDING DOMAIN; LIGAND-BINDING; EVOLUTION; CLONING;
Keywords:
hydroxysteroid dehydrogenases; vertebrate evolution; xenobiotics; endocrine disrupters;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Baker, ME Univ Calif San Diego, Dept Med, 0823,9500 Gilman Dr, La Jolla, CA 92093 USA Univ Calif San Diego 0823,9500 Gilman Dr La Jolla CA USA 92093 A
Citazione:
M.E. Baker, "Hydroxysteroid dehydrogenases: ancient and modern regulators of adrenal and sex steroid action", MOL C ENDOC, 175(1-2), 2001, pp. 1-4

Abstract

The adrenal and sex steroids receptor clade arose from an ancestral nuclear receptor in a primitive vertebrate at least 540 million years ago during the early Cambrian. At that time, these receptors had less specificity for their canonical ligands than their descendents in mammals have, which raises the question of how specificity for responses to different steroids was regulated. We propose that hydroxysteroid dehydrogenases that metabolized functional groups at different sites on steroids (e.g. C3, C11, C17 and C20) had a key role in providing specificity for steroid regulation of gene transcription in primitive vertebrates. Later, with increased physiological complexity in land animals due to innovations such as the placenta, hydroxysteroid dehydrogenases were recruited for new roles in regulating steroid-mediated physiological responses. Hydroxysteroid dehydrogenases in fish, amphibia and mammals are likely have different affinities for some xenobiotics, which needs to be considered in evaluating their hazards as endocrine disrupters. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 19:21:21