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Titolo:
Loss of HCF-1-chromatin association precedes temperature-induced growth arrest of tsBN67 cells
Autore:
Wysocka, J; Reilly, PT; Herr, W;
Indirizzi:
Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA Cold Spring Harbor Lab Cold Spring Harbor NY USA 11724 rbor, NY 11724 USA SUNY Stony Brook, Program Mol & Cellular Biol, Stony Brook, NY 11794 USA SUNY Stony Brook Stony Brook NY USA 11794 Biol, Stony Brook, NY 11794 USA
Titolo Testata:
MOLECULAR AND CELLULAR BIOLOGY
fascicolo: 11, volume: 21, anno: 2001,
pagine: 3820 - 3829
SICI:
0270-7306(200106)21:11<3820:LOHAPT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
HERPES-SIMPLEX VIRUS; AMINO-TERMINAL DOMAIN; ACTIVATION DOMAIN; REPRESSOR SIN3; HCF; VP16; PROTEIN; COMPLEX; FAMILY; LUMAN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Herr, W Cold Spring Harbor Lab, POB 100,1 Bungtown Rd, Cold Spring Harbor,NY 11724 USA Cold Spring Harbor Lab POB 100,1 Bungtown Rd Cold Spring Harbor NY USA 11724
Citazione:
J. Wysocka et al., "Loss of HCF-1-chromatin association precedes temperature-induced growth arrest of tsBN67 cells", MOL CELL B, 21(11), 2001, pp. 3820-3829

Abstract

Human HCF-1 is a large, highly conserved, and abundant nuclear protein that plays an important but unknown role in cell proliferation. It also plays a role in activation of herpes simplex virus immediate-early gene transcription by the viral regulatory protein VP16. A single proline-to-serine substitution in the HCF-1 VP16 interaction domain causes a temperature-induced arrest of cell proliferation in hamster tsBN67 cells and prevents transcriptional activation by VP16, We show here that HCF-1 is naturally bound to chromatin in uninfected tells through its VP16 interaction domain. HCF-1 is chromatin bound in tsSN67 cells at permissive temperature but dissociates from chromatin before tsBN67 cells stop proliferating at the nonpermissive temperature, suggesting that loss of HCF-1 chromatin association is the primary cause of the temperature-induced tsBN67 cell proliferation arrest. We propose that the role of HCF-1 in cell proliferation is to regulate gene transcription by associating with a multiplicity of DNA-bound transcription factors through its VP16 interaction domain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 08:56:46