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Titolo:
Vav1 regulates phospholipase C gamma activation and calcium responses in mast cells
Autore:
Manetz, TS; Gonzalez-Espinosa, C; Arudchandran, R; Xirasagar, S; Tybulewicz, V; Rivera, J;
Indirizzi:
NIAMSD, Sect Chem Immunol, NIH, Bethesda, MD 20892 USA NIAMSD Bethesda MDUSA 20892 ct Chem Immunol, NIH, Bethesda, MD 20892 USA Natl Inst Med Res, London NW7 1AA, England Natl Inst Med Res London England NW7 1AA ed Res, London NW7 1AA, England
Titolo Testata:
MOLECULAR AND CELLULAR BIOLOGY
fascicolo: 11, volume: 21, anno: 2001,
pagine: 3763 - 3774
SICI:
0270-7306(200106)21:11<3763:VRPCGA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
AFFINITY IGE RECEPTOR; FC-EPSILON-RI; JUN NH2-TERMINAL KINASE; EXCHANGE FACTOR VAV; T-CELL; ANTIGEN RECEPTOR; PROTOONCOGENE PRODUCT; TYROSINE PHOSPHORYLATION; SIGNALING PATHWAY; B-CELL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Rivera, J NIAMSD, Sect Chem Immunol, NIH, Bldg 10,Room 9N228,10 Ctr Dr,MSC1820, Bethesda, MD 20892 USA NIAMSD Bldg 10,Room 9N228,10 Ctr Dr,MSC 1820 Bethesda MD USA 20892
Citazione:
T.S. Manetz et al., "Vav1 regulates phospholipase C gamma activation and calcium responses in mast cells", MOL CELL B, 21(11), 2001, pp. 3763-3774

Abstract

The hematopoietic cell-specific protein Vav1 is a substrate of tyrosine kinases activated following engagement of many receptors, including Fc epsilon RI. Vav1-deficient mice contain normal numbers of mast cells but respond more weakly than their normal counterparts to a passive systemic anaphylaxis challenge. Vav1-deficient bone marrow-derived mast cells also exhibited reduced degranulation and cytokine production, although tyrosine phosphorylation of FceRI, Syk, and LAT (linker for activation of T cells) was normal. In contrast, tyrosine phosphorylation of phospholipase C gamma1 (PLC gamma1) and PLC gamma2 and calcium mobilization were markedly inhibited. Reconstitution of deficient mast cells with Vav1 restored normal tyrosine phosphorylation of PLC gamma1 and PLC gamma2 and calcium responses, Thus, Vav1 is essential to Fc epsilon RI-mediated activation of PLC gamma and calcium mobilization in mast cells, In addition to its known role as an activator of Rac1 GTPases, these findings demonstrate a novel function for Vav1 as a regulator of PLC gamma -activated calcium signals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:42:44