Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of electrical stimulation of the gasserian ganglion on regional cerebral blood flow after induced subarachnoid hemorrhage in pigs evaluated by Tc-99m-HMPAO-SPECT
Autore:
Ebel, H; Semmelmann, G; Friese, M; Volz, M; Lee, JY; Duck, M; Schomacker, K; Varga, J; Furka, I; Schroder, R; Klug, N;
Indirizzi:
Univ Cologne, Dept Neurosurg, D-50924 Cologne, Germany Univ Cologne Cologne Germany D-50924 Neurosurg, D-50924 Cologne, Germany Univ Cologne, Dept Anesthesiol & Intens Care, D-50924 Cologne, Germany Univ Cologne Cologne Germany D-50924 tens Care, D-50924 Cologne, Germany Univ Cologne, Dept Nucl Med, D-50924 Cologne, Germany Univ Cologne Cologne Germany D-50924 Nucl Med, D-50924 Cologne, Germany Univ Cologne, Dept Pathol, D-50924 Cologne, Germany Univ Cologne CologneGermany D-50924 pt Pathol, D-50924 Cologne, Germany Debrecen Univ Med, Dept Nucl Med, H-4012 Debrecen, Hungary Debrecen Univ Med Debrecen Hungary H-4012 Med, H-4012 Debrecen, Hungary Debrecen Univ Med, Dept Expt Surg, H-4012 Debrecen, Hungary Debrecen Univ Med Debrecen Hungary H-4012 Surg, H-4012 Debrecen, Hungary
Titolo Testata:
MINIMALLY INVASIVE NEUROSURGERY
fascicolo: 1, volume: 44, anno: 2001,
pagine: 50 - 57
SICI:
0946-7211(200103)44:1<50:EOESOT>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPINAL-CORD STIMULATION; SUBSTANCE-P; SPHENOPALATINE GANGLION; INTRACRANIAL-PRESSURE; PIAL-ARTERIES; ANIMAL-MODEL; VASOSPASM; RAT; HEMODYNAMICS; CIRCULATION;
Keywords:
rCBF; SAM; SPECT; trigeminal stimulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Ebel, H Univ Cologne, Dept Neurosurg, Joseph Stelzmann Str 9, D-50924 Cologne, Germany Univ Cologne Joseph Stelzmann Str 9 Cologne Germany D-50924 rmany
Citazione:
H. Ebel et al., "Effects of electrical stimulation of the gasserian ganglion on regional cerebral blood flow after induced subarachnoid hemorrhage in pigs evaluated by Tc-99m-HMPAO-SPECT", MIN IN NEUR, 44(1), 2001, pp. 50-57

Abstract

It could be demonstrated that cervical spinal cord stimulation increases cerebral blood flow. The effects of electrical stimulation of the trigeminalganglion in the acute phase of SAM in pigs were investigated. The experiments were carried out on 11 domestic pigs divided in two groups (group I: SAM [n = 5]; group II: SAM and trigeminal stimulation [n = 6]). In all animals a native SPECT was performed. The Gasserian ganglion was exposed for inserting the stimulation electrode. SAH was induced by injecting 10 mi autologous blood through a catheter placed in the suprasellar cistern. 30 minutes after SAM-induction electrical stimulation was started for two hours in group 11 (2.8-4.5 V, 50Hz, 300 mus). Tc-99m-HMPAO (400-540 MBq) was injected intravenousely 110 minutes later. In group I 99mTc-HMPAO was applied after the same time interval. 80 minutes later SPECT was performed. Data were processed to calculate the uptake of radioactivity (%/kg tissue weight). The mean values were calculated for the different groups: native animal examination (%/kg tissue weight): 0.6343; group I: 0.468; group II: 0.6533. Comparing the mean values a highly significant difference between group I and groupII (p <0.01) and between native examination and group I (p<0.01) could be found. No statistical significance could be detected on comparing the left/right-ratio in any ROI. The electrical stimulation of the Gasserian ganglion leads to a significantly increased uptake of Tc-99m-HMPAO after induced SAM. Maybe the stimulation of the Gasserian ganglion constitutes a new therapeutic modality treating disturbed rCBF after SAH.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/06/19 alle ore 17:44:54