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Titolo:
Altered mechanisms underlying hypoxic dilation of skeletal muscle resistance arteries of hypertensive versus normotensive Dahl rats
Autore:
Frisbee, JC; Roman, RJ; Krishna, UM; Falck, JR; Lombard, JH;
Indirizzi:
Med Coll Wisconsin, Dept Physiol, Milwaukee, WI 53226 USA Med Coll Wisconsin Milwaukee WI USA 53226 hysiol, Milwaukee, WI 53226 USA Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75235 USA Univ Texas Dallas TX USA 75235 ed Ctr, Dept Biochem, Dallas, TX 75235 USA
Titolo Testata:
MICROCIRCULATION
fascicolo: 2, volume: 8, anno: 2001,
pagine: 115 - 127
SICI:
1073-9688(200104)8:2<115:AMUHDO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXYGEN-TENSION; NITRIC-OXIDE; K+ CHANNELS; INCREASES; RESPONSES; SHR;
Keywords:
arachidonic acid epoxidation; arachidonic acid omega-hydroxylation; cytochrome P430 4A enzymes; 20-HETE; hypoxia; indomethaein; L-NAME; MS-PPOH; 17-ODYA; vascular reactivity; vascular smooth muscle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Frisbee, JC Med Coll Wisconsin, Dept Physiol, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA Med Coll Wisconsin 8701 Watertown Plank Rd Milwaukee WI USA 53226
Citazione:
J.C. Frisbee et al., "Altered mechanisms underlying hypoxic dilation of skeletal muscle resistance arteries of hypertensive versus normotensive Dahl rats", MICROCIRCUL, 8(2), 2001, pp. 115-127

Abstract

Objective: To determine mechanisms underlying hypoxic dilation of skeletalmuscle resistance arteries from normotensive (NT) and hypertensive (HT) Dahl salt-sensitive (SS) rats. Methods: Isolateral graeilis arteries (GA) from both rat groups were viewed via television microscopy and vascular responses to a reduction in PO2 from 145 mm Hg to 40 mm Hg were measured with a video micrometer. Responses were determined following endothelium removal and following inhibition of specific biochemical pathways regulating vascular tone. Results: Hypoxic dilation was impaired in HT rats versus NT controls. Endothelium removal abolished hypoxic dilation in NT rats, although a significant dilation to hypoxia remained in vessels from HT animals. Inhibition of cytochrome P450 (CP450) 4A enzymes blunted hypoxic dilation in both groups, while inhibition of epoxyeicosatrienoic acid (EET) production impaired responses in NT rats only. Inhibition of 20-hydroxyeicosatetraenoic acid (20-HETE) production or blockade of membrane receptors for 20-HETE reduced hypoxic dilation in HT rats, with minimal effects in NT animals. Nitric oxide synthase inhibition had no effect on hypoxic dilation in either group, while cycloxygenase inhibition significantly reduced this response in both groups. Conclusions: These results suggest that the mechanisms of hypoxic dilationin GA from NT Dahl-SS rats are altered with HT, impairing the response to reduced PO2. While hypoxia induced substantial prostanoid release in both groups, the role of CP450 4A enzymes is shifted from EET production in NT rats toward inhibition of 20-HETE, production in HT rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 22:39:02