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Titolo:
The Na+/Ca2+ exchanger as a culprit of myocardial stunning.
Autore:
Mosca, SM; Cingolani, HE;
Indirizzi:
Natl Univ La Plata, Ctr Invest Cardiovasc, Fac Ciencias Med, RA-1900 La Plata, Argentina Natl Univ La Plata La Plata Argentina RA-1900 A-1900 La Plata, Argentina
Titolo Testata:
MEDICINA-BUENOS AIRES
fascicolo: 2, volume: 61, anno: 2001,
pagine: 167 - 173
SICI:
0025-7680(2001)61:2<167:TNEAAC>2.0.ZU;2-G
Fonte:
ISI
Lingua:
SPA
Soggetto:
CORONARY-ARTERY OCCLUSION; INTRACELLULAR SODIUM; CALCIUM OVERLOAD; NA+/H+ EXCHANGE; CA2+ OVERLOAD; INFARCT SIZE; RABBIT HEART; REVERSE MODE; ISCHEMIA; REPERFUSION;
Keywords:
Na+/H+ blockade; Na+/Ca2+ blockade; myocardial stunning; ischemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Cingolani, HE Natl Univ La Plata, Ctr Invest Cardiovasc, Fac Ciencias Med,60 & 120, RA-1900 La Plata, Argentina Natl Univ La Plata 60 & 120 La Plata Argentina RA-1900 tina
Citazione:
S.M. Mosca e H.E. Cingolani, "The Na+/Ca2+ exchanger as a culprit of myocardial stunning.", MEDICINA, 61(2), 2001, pp. 167-173

Abstract

Our objective was to assess the participation of Na+/H+ exchanger (NHE) and Na+/Ca2+ exchanger (NCX) on systolic and diastolic alterations of myocardial stunning. Isolated perfused rat hearts were submitted to 20 min of global ischemia (Is) followed by 30 min of reperfusion (R). This protocol was repeated after treatment before ischemia and/or early in R. with HOE 642 1 muM, a specific blocker of NHE-1 and KB-R7943 1 muM the novel inhibitor of the reverse mode of NCX. In control ischemic hearts the contractility assessed through +dP/dt(max) recovered approximately 60%. When the NHE blockade was performed before Is or early in R the postischemic recovery reached 100%. The blockade of the reverse mode of NCX only improved significantly the recovery when administered before Is and early in R (95 +/- 7%). The ischemic contracture decreased when the treatment with both blockers was performedbefore Is. During R the increase of end diastolic pressure (EDP) observed in control ischemic hearts (at 30 min of R, EDP value was 44 +/- 4 mmHg) diminished significantly by NHE (24 +/- 6 and 12 +/- 2 mmHg when the blocker was administered before or after Is) and NCX blockade performed before and after Is (12 +/- 6 mmHg). These results indicate that the activation of thereverse mode of NCX secondary to the NHE activation during ischemia and reperfusion is the mechanism responsible for the Ca2+ overload involved in the diminution of contractility that characterizes myocardial stunning.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 07:30:46