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Titolo:
Changes in tissue cellularity are associated with growth enhancement in genetically modified arctic char (Salvelinus alpinus L.) carrying recombinantgrowth hormone gene
Autore:
Pitkanen, TI; Xie, SQ; Krasnov, A; Mason, PS; Molsa, H; Stickland, NC;
Indirizzi:
Univ Kuopio, Inst Appl Biotechnol, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 otechnol, FIN-70211 Kuopio, Finland Univ London Royal Vet Coll, Dept Vet Basic Sci, London NW1 0TU, England Univ London Royal Vet Coll London England NW1 0TU ondon NW1 0TU, England
Titolo Testata:
MARINE BIOTECHNOLOGY
fascicolo: 2, volume: 3, anno: 2001,
pagine: 188 - 197
SICI:
1436-2228(200103/04)3:2<188:CITCAA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
TROUT SALMO-GAIRDNERI; EXOGENOUS PORCINE SOMATOTROPIN; SATELLITE CELL-PROLIFERATION; MUSCLE-FIBER CHARACTERISTICS; SKELETAL-MUSCLE; RAINBOW-TROUT; ATLANTIC SALMON; HISTOCHEMICAL CHARACTERIZATION; MYOTOMAL MUSCLE; SOMATIC GROWTH;
Keywords:
gene transfer; growth hormone; Salmonidae; tissue cellularity; hyperplasia; hypertrophy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Pitkanen, TI Univ Kuopio, Inst Appl Biotechnol, POB 1627, FIN-70211 Kuopio, Finland Univ Kuopio POB 1627 Kuopio Finland FIN-70211 uopio, Finland
Citazione:
T.I. Pitkanen et al., "Changes in tissue cellularity are associated with growth enhancement in genetically modified arctic char (Salvelinus alpinus L.) carrying recombinantgrowth hormone gene", MAR BIOTEC, 3(2), 2001, pp. 188-197

Abstract

Biochemical and histological analyses were used to study the number and size of cells (cellularity in tissues of fast-growing, genetically modified Arctic char (Salvelinus alpinus L.), overexpressing sockeye salmon (Oncorhynchus nerka) growth hormone gene (OnGH1). DNA contents of muscle, heart, andliver were compared in transformed, sibling (age control) and 1 year older(size control) char. Total white muscle cross-sectional area, white musclefiber number, and total nuclei number within the muscle tissue were determined from one complete half-section of each fish. The analyzed tissues responded differently to growth hormone overproduction. In muscle tissue of OnGH1-transformed char, the enhanced growth was clearly associated with proliferation of muscle cells (hyperplasia), whereas in heart tissue both cell proliferation and increase in cell size (hypertrophy) were enhanced. The relative DNA concentration in the liver of transformed char was significantly greater than that of control fish, suggesting reduction in size of hepatic cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/02/20 alle ore 02:28:26