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Titolo:
Molecular cloning and genomic structure of a gene encoding interferon regulatory factor in the pufferfish (Fugu rubripes)
Autore:
Richardson, MP; Tay, BH; Goh, BY; Venkatesh, B; Brenner, S;
Indirizzi:
Inst Mol & Cell Biol, Singapore 117609, Singapore Inst Mol & Cell Biol Singapore Singapore 117609 gapore 117609, Singapore
Titolo Testata:
MARINE BIOTECHNOLOGY
fascicolo: 2, volume: 3, anno: 2001,
pagine: 145 - 151
SICI:
1436-2228(200103/04)3:2<145:MCAGSO>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRON-EXON ORGANIZATION; TRANSCRIPTION FACTOR; INDUCIBLE GENES; IRF-2 GENES; FACTOR-I; IFN; SYSTEM; DNA; SEQUENCE; ELEMENTS;
Keywords:
fugu; IRF gene; exon-intron structure; promoter;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Venkatesh, B Inst Mol & Cell Biol, 30 Med Dr, Singapore 117609, Singapore Inst Mol & Cell Biol 30 Med Dr Singapore Singapore 117609 re
Citazione:
M.P. Richardson et al., "Molecular cloning and genomic structure of a gene encoding interferon regulatory factor in the pufferfish (Fugu rubripes)", MAR BIOTEC, 3(2), 2001, pp. 145-151

Abstract

Interferon regulatory factors (IRFs) are a large family of transcription factors involved in regulating the transcriptional response of vertebrates to interferons and viral infection. In this report we describe the cloning and genomic organization of an IRF gene from the pufferfish (Fugu rubripes). The fugu IRF gene spans 2.7 kb from the transcription start site to the polyadenylation signal. It consists of 10 exons and 9 introns and encodes a protein of 296 amino acids. The overall amino acid sequence of fugu IRF displays 55% identity to flounder IRF and approximately 44% identity to avian and mammalian IRF-1 and IRF-2. On the basis of the genomic structure and theabsence of a transcriptional repression domain, we conclude that the fugu IRF is a member of the IRF-1 family. The fugu IRF gene is expressed in a wide range of tissues. While a single transcript of 1.4 kb was detected in most tissues, several larger transcripts generated using alternative polyadenylation signals were found in the gills.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 09:42:57