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Titolo:
Primary central nervous system lymphomas express VH genes with intermediate to high somatic mutations
Autore:
Sekita, T; Tamaru, JI; Kaito, K; Katayama, T; Kobayashi, M; Mikata, A;
Indirizzi:
Jikei Univ, Sch Med, Minato Ku, Tokyo, Japan Jikei Univ Tokyo JapanJikei Univ, Sch Med, Minato Ku, Tokyo, Japan
Titolo Testata:
LEUKEMIA & LYMPHOMA
fascicolo: 3-4, volume: 41, anno: 2001,
pagine: 377 - 385
SICI:
1042-8194(200104)41:3-4<377:PCNSLE>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACQUIRED-IMMUNODEFICIENCY-SYNDROME; LYMPHOCYTE HOMING RECEPTOR; PRIMARY BRAIN LYMPHOMAS; LARGE-CELL LYMPHOMA; EPSTEIN-BARR-VIRUS; CENTER B-CELLS; H GENES; AFFINITY MATURATION; CLONAL EXPANSION; DEFICIENT MICE;
Keywords:
PCNSL; diffuse large B cell lymphoma; VH sequence; somatic mutation; primary CNS lymphomas;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Sekita, T Jikei Univ, Sch Med, Minato Ku, 3-25-8 Nishishinbashi, Tokyo, Japan Jikei Univ 3-25-8 Nishishinbashi Tokyo Japan shi, Tokyo, Japan
Citazione:
T. Sekita et al., "Primary central nervous system lymphomas express VH genes with intermediate to high somatic mutations", LEUK LYMPH, 41(3-4), 2001, pp. 377-385

Abstract

Primary central nervous system lymphoma (PCNSL) is a rare disease, especially among non-AIDS patients. Although almost all PCNSLs belong to the diffuse large B-cell lymphoma (DLBL) category. its clinical course differs from that of other types of DLBL. To elucidate the histogenesis of PCNSL. we analyzed thr sourer of the cells from its variable region (VH) sequences usingthe polymerase chain reaction (PCR) method to amplify the immunoglobulin heavy chain (IgH) gene of DNA extracted from paraffin sections. Fifteen patients with AIDS-unrelated PCNSL of DLBL type, (7 malts and 8 females), were evaluated. Only one case showed positive evidence of EBV infection. The prognosis was very ports with a median survival of 9 months. Analysis of the VH sequences revealed that the VH4 family was used in 4 cases and the VH3 family in 2 cases. The homology with previously published germline sequences was random. ranging from 82.7-93.2%. showing intermediate to high somatic mutations. In 3 of 6 cases, the existence of intraclonal diversity was suspected. These findings suggest that PCNSLs are histogenetically derived from antigen selected B cells in the germinal center (GC) environment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/10/20 alle ore 00:37:39