Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Delayed, reversible hearing loss caused by difluoromethylornithine (DFMO)
Autore:
Doyle, KJ;
Indirizzi:
Univ Calif Davis, Dept Otolaryngol Head & Neck Surg, Sacramento, CA 95817 USA Univ Calif Davis Sacramento CA USA 95817 k Surg, Sacramento, CA 95817 USA
Titolo Testata:
LARYNGOSCOPE
fascicolo: 5, volume: 111, anno: 2001,
pagine: 781 - 785
SICI:
0023-852X(200105)111:5<781:DRHLCB>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
EAR ORNITHINE DECARBOXYLASE; ALPHA-DIFLUOROMETHYLORNITHINE; INNER-EAR; TRIAL; OTOTOXICITY; POLYAMINES;
Keywords:
difluoromethylornithine; DFMO; ototoxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Doyle, KJ Univ Calif Davis, Dept Otolaryngol Head & Neck Surg, 2521 Stockton Blvd,Ste 7200, Sacramento, CA 95817 USA Univ Calif Davis 2521 Stockton Blvd,Ste 7200 Sacramento CA USA 95817
Citazione:
K.J. Doyle, "Delayed, reversible hearing loss caused by difluoromethylornithine (DFMO)", LARYNGOSCOP, 111(5), 2001, pp. 781-785

Abstract

Objectives/Hypothesis: Difluoromethylornithine (DFMO) is an anticancer experimental drug that is ototoxic, The objectives of these three experiments were to: 1) determine a dose and dosing schedule of DFMO that produces significant hearing loss (HL) in newborn gerbils; 2) compare the HL level for control and newborn gerbils receiving daily subcutaneous injections of DFMO;and 3) to determine if DFMO-related HL is significantly reversible following discontinuation of DFMO treatment. Study Design: Prospective, non-randomized experimental design with placebo controls. Methods: Click-evoked auditory brainstem response (ABR) testing was performed for al-day-old Mongoliangerbils following daily subcutaneous injections of DFMO or saline. Three experiments were carried out using different injection schedules and doses of DFMO, In experiment 3, animals were retested at 42 days of age following a S-week recovery from DFMO, Results: Animals administered an 18-day regimen of DFMO at 1 g/kg per day (from day 3 to day 20) had click thresholds of 25 to 65 dB nHL, whereas animals receiving daily injections of saline had thresholds of 5 to 20 dB nHL, Animals retested after 3 weeks of recovery from DFMO treatment had thresholds ranging from 5 to 20 dB nHL, Differences were statistically significant. Conclusions: DFMO causes mild to moderate HL in neonatal gerbils that recovers after discontinuation of the drug.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 13:25:43