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Titolo:
Effect of early interferon treatment on conversion to definite multiple sclerosis: a randomised study
Autore:
Comi, G; Filippi, M; Barkhof, F; Durelli, L; Edan, G; Fernandez, O; Hartung, HP; Seeldrayers, P; Sorensen, PS; Rovaris, M; Martinelli, V; Hommes, OR;
Indirizzi:
IRCCS Osped San Raffaele, Dept Neurosci, Multiple Sclerosis Ctr, I-20132 Milan, Italy IRCCS Osped San Raffaele Milan Italy I-20132 s Ctr, I-20132 Milan, Italy Vrije Univ Amsterdam, Med Ctr, Dept Radiol, Multiple Sclerosis Magnet Resonance Ctr, Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands Ctr, Amsterdam, Netherlands Univ Turin, Dept Neurosci, Turin, Italy Univ Turin Turin ItalyUniv Turin, Dept Neurosci, Turin, Italy Univ Rennes, Neurol Clin, Rennes, France Univ Rennes Rennes FranceUniv Rennes, Neurol Clin, Rennes, France Hosp Carlos Haya, Serv Neurol, Malaga, Spain Hosp Carlos Haya Malaga Spain p Carlos Haya, Serv Neurol, Malaga, Spain Karl Franzens Univ Graz, Dept Neurol, Graz, Austria Karl Franzens Univ Graz Graz Austria v Graz, Dept Neurol, Graz, Austria CHU Charleroi, Dept Neurol, Charleroi, Italy CHU Charleroi Charleroi Italy Charleroi, Dept Neurol, Charleroi, Italy Free Univ Brussels, Hop Erasme, B-1070 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1070 sme, B-1070 Brussels, Belgium Rigshosp, Dept Neurol, DK-2100 Copenhagen, Denmark Rigshosp Copenhagen Denmark DK-2100 Neurol, DK-2100 Copenhagen, Denmark European Charcot Fdn, Nijmegen, Netherlands European Charcot Fdn Nijmegen Netherlands ot Fdn, Nijmegen, Netherlands
Titolo Testata:
LANCET
fascicolo: 9268, volume: 357, anno: 2001,
pagine: 1576 - 1582
SICI:
0140-6736(20010519)357:9268<1576:EOEITO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLINICALLY ISOLATED SYNDROMES; ENHANCED MRI LESIONS; PROGNOSTIC VALUE; OPTIC NEURITIS; AXONAL DAMAGE; BRAIN MRI; FOLLOW-UP; DEMYELINATION; DISABILITY; GUIDELINES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Comi, G IRCCS Osped San Raffaele, Dept Neurosci, Multiple Sclerosis Ctr, Via Olgettina 60, I-20132 Milan, Italy IRCCS Osped San Raffaele Via Olgettina 60 Milan Italy I-20132 aly
Citazione:
G. Comi et al., "Effect of early interferon treatment on conversion to definite multiple sclerosis: a randomised study", LANCET, 357(9268), 2001, pp. 1576-1582

Abstract

Background Interferon beta reduces activity in multiple sclerosis as measured clinically and by magnetic resonance imaging (MRI). We assessed the effect of interferon beta-1a on the occurrence of relapses in patients after first presentation with neurological events, who are at high risk of conversion to clinically definite multiple sclerosis. Methods Eligible patients had had a first episode of neurological dysfunction suggesting multiple sclerosis within the previous 3 months and had strongly suggestive brain MRI findings. Patients were randomly assigned interferon beta-1a 22 mug or placebo subcutaneously once weekly for 2 years. Neurological and clinical assessments were done every 6 months and brain MRI every 12 months. Analyses excluded one patient assigned placebo who received no study injections. Findings 241 (78%) of 308 randomised patients received study treatment for2 years; 278 (90%) remained in the study until termination. 57 (85%) of 67who stopped therapy did so after conversion to clinically definite multiple sclerosis. Fewer patients developed clinically definite multiple sclerosis in the interferon group than in the placebo group (52/154 [34%] vs 69/154[45%]; p=0.047). The time at which 30% of patients had converted to clinically definite multiple sclerosis was 569 days in the interferon group and 252 in the placebo group (p=0.034). The annual relapse rates were 0.33 and 0.43 (p=0.045). The number of new T2-weighted MRI lesions and the increase in lesion burden were significantly lower with active treatment. Interpretation Interferon beta-1a treatment at an early stage of multiple sclerosis had significant positive effects on clinical and MRI outcomes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 15:34:05