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Titolo:
Oxidative modification of low-density lipoproteins and the outcome of renal allografts at 1 1/2 years
Autore:
Bosmans, JL; Holvoet, P; Dauwe, SEH; Ysebaert, DK; Chapelle, T; Jurgens, A; Kovacic, V; Van Marck, EA; De Broe, ME; Verpooten, GA;
Indirizzi:
Univ Antwerp Hosp, Dept Nephrol, Antwerp, Belgium Univ Antwerp Hosp Antwerp Belgium Hosp, Dept Nephrol, Antwerp, Belgium Univ Antwerp Hosp, Dept Transplantat Surg, Antwerp, Belgium Univ Antwerp Hosp Antwerp Belgium t Transplantat Surg, Antwerp, Belgium Univ Antwerp Hosp, Dept Pathol, Antwerp, Belgium Univ Antwerp Hosp Antwerp Belgium p Hosp, Dept Pathol, Antwerp, Belgium Catholic Univ Leuven, Ctr Mol & Vasc Biol, Louvain, Belgium Catholic Univ Leuven Louvain Belgium Mol & Vasc Biol, Louvain, Belgium
Titolo Testata:
KIDNEY INTERNATIONAL
fascicolo: 6, volume: 59, anno: 2001,
pagine: 2346 - 2356
SICI:
0085-2538(200106)59:6<2346:OMOLLA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSPLANT RECIPIENTS; ATHEROGENIC LIPOPROTEINS; GENE-EXPRESSION; MESANGIAL CELLS; ACUTE REJECTION; RISK-FACTORS; DISEASE; ATHEROSCLEROSIS; GLOMERULOSCLEROSIS; HYPERLIPIDEMIA;
Keywords:
oxidized LDL; kidney graft; transplantation; chronic allograft nephropathy; high density lipoprotein; end-stage renal disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Verpooten, GA Univ Antwerp, Univ Antwerp Hosp, Dept Nephrol Hypertens, Wilrijkstr 10, B-2650 Edegem, Belgium Univ Antwerp Wilrijkstr 10 Edegem Belgium B-2650 m, Belgium
Citazione:
J.L. Bosmans et al., "Oxidative modification of low-density lipoproteins and the outcome of renal allografts at 1 1/2 years", KIDNEY INT, 59(6), 2001, pp. 2346-2356

Abstract

Background. Previous studies reported a significant association between hyperlipidemia of the recipient and chronic allograft nephropathy (CAN). However, the nature and the patho genic mechanism of circulating lipid abnormalities in CAN remain unclear. Methods. In a prospective study of 50 consecutive adult recipients of a cadaveric renal allograft, we investigated the impact of lipid abnormalities on the outcome of the graft at 1 1/2, years. Besides morphometric analysis of implantation and protocol biopsies, clinical and biochemical variables were studied at three-month intervals. Plasma concentrations of oxidized low-density lipoprotein (OxLDL) were determined by means of enzyme-linked immunosorbent assay. Immunohistochemical staining for OxLDL and macrophages wasperformed on paired renal biopsies. Study end points were the fractional interstitial volume and the 24-hour creatinine clearance at 1 1/2 years. Results. High-density lipoprotein (HDL) cholesterol of the recipient less than or equal to 47 mg/dL was a risk factor for the functional (RR = 1.56; 95% CI, 0.978 to 2.497) and the morphological (RR = 2.75; 95% CI, 1.075 to 7.037) outcome of the graft, mainly in patients without acute rejection (RR= 2.03; 95% CI, 1.13 to 3.65, and RR = 4.67; 95% CI, 1.172 to 18.582, respectively). Interstitial accumulation of OxLDL was inversely associated withHDL cholesterol (R = -0.476, P = 0.019), and was associated with a higher density of tubulointerstitial macrophages (R = 0.656, P = 0.001) and a higher fractional interstitial volume at 1 1/2 years (P = 0.049). Conclusion. Decreased HDL cholesterol levels of the recipient adversely affect the outcome of renal allografts through the accumulation of OxLDL in the renal interstitium of the graft. Interstitial accumulation of OxLDL was associated with the presence of macrophages and the development of interstitial fibrosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 20:10:01