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Titolo:
Fluvastatin suppresses oxidative stress and fibrosis in the interstitium of mouse kidneys with unilateral ureteral obstruction
Autore:
Moriyama, T; Kawada, N; Nagatoya, K; Takeji, M; Horio, M; Ando, A; Imai, E; Hori, M;
Indirizzi:
Osaka Univ, Grad Sch Med, Dept Internal Med & Therapeut A8, Sch Hlth & Sport Sci, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 ort Sci, Suita, Osaka 5650871, Japan
Titolo Testata:
KIDNEY INTERNATIONAL
fascicolo: 6, volume: 59, anno: 2001,
pagine: 2095 - 2103
SICI:
0085-2538(200106)59:6<2095:FSOSAF>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
COA REDUCTASE INHIBITOR; RAT MESANGIAL CELLS; SMOOTH MUSCLE ACTIN; EXPERIMENTAL HYDRONEPHROSIS; IGA NEPHROPATHY; LIPID-PEROXIDATION; HYDROGEN-PEROXIDE; HEME OXYGENASE; IN-VITRO; EXPRESSION;
Keywords:
HMG-CoA reductase inhibitor; kidney injury; antioxidant therapy; tubulointerstitial fibrosis; advanced glycation end products; heme oxygenase-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Moriyama, T Osaka Univ, Grad Sch Med, Dept Internal Med & Therapeut A8, Sch Hlth & Sport Sci, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 0871, Japan
Citazione:
T. Moriyama et al., "Fluvastatin suppresses oxidative stress and fibrosis in the interstitium of mouse kidneys with unilateral ureteral obstruction", KIDNEY INT, 59(6), 2001, pp. 2095-2103

Abstract

Background. Recently, we demonstrated increased oxidative stress in the interstitium of ureteral obstructed kidneys based on the increased expressionof heme oxygenase-l and immunohistochemical detection of advanced glycation end products (AGE) in the interstitium. Antioxidant therapy may have a therapeutic potential toward interstitial fibrosis of unilateral ureteral obstruction (UUO) kidneys. Fluvastatin is an HMG-CoA reductase inhibitor and has been demonstrated to have an antioxidant activity in vitro. Methods. The effects of fluvastatin on UUO kidneys from the viewpoints of antioxidant action in vivo and antifibrosis action were studied. To investigate the antioxidant action and its therapeutic efficacy of fluvastatin in UUO kidneys, AGE accumulation and fibrosis in the obstructed kidneys was compared among vehicle-, pravastatin-, or fluvastatin-treated (10 or 40 mg/kg/day) groups. Results. Tubulointerstitial fibrosis was significantly attenuated in fluvastatin-treated animals. Fluvastatin significantly suppressed the degree of immunostaining of AGE in UUO kidneys. Conclusions. These results provide evidence fur the antioxidant action of fluvastatin in vivo. The decreased interstitial fibrosis along with a decreased oxidative stress marker in the interstitial lesion strongly suggests the existence of a causal relationship between them. Fluvastatin may have therapeutic value in slowing or preventing interstitial fibrosis in progressive renal disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 00:41:01