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Titolo:
Lupus: Why women?
Autore:
Greenstein, BD;
Indirizzi:
Univ Arizona, Coll Med, Arizona Arthrit Ctr, Tucson, AZ 85724 USA Univ Arizona Tucson AZ USA 85724 rizona Arthrit Ctr, Tucson, AZ 85724 USA
Titolo Testata:
JOURNAL OF WOMENS HEALTH & GENDER-BASED MEDICINE
fascicolo: 3, volume: 10, anno: 2001,
pagine: 233 - 239
SICI:
1524-6094(200104)10:3<233:LWW>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUS AUTOIMMUNE-DISEASE; ESTROGEN-RECEPTOR-ALPHA; MRL/MP-LPR/LPR MICE; PROGESTERONE RECEPTORS; IMMUNE-COMPLEXES; RAT-BRAIN; AROMATASE INHIBITOR; RETROVIRAL GP70; GUINEA-PIG; F1 MICE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Greenstein, BD Univ Arizona, Coll Med, Arizona Arthrit Ctr, 1051 N Campbell Ave, Tucson, AZ 85724 USA Univ Arizona 1051 N Campbell Ave Tucson AZ USA 85724 24 USA
Citazione:
B.D. Greenstein, "Lupus: Why women?", J WOMEN H G, 10(3), 2001, pp. 233-239

Abstract

Estrogens are believed to play a role in the etiology of both human and murine systemic lupus erythematosus (lupus, SLE), presumably through the agency of their cellular receptor proteins. There is now considerable interest in the molecular mechanism of action of estrogens in immune tissues, particularly with regard to autoimmune disorders, which are generally more prevalent in women. In this laboratory, an attempt is being made to characterize estrogen receptors in murine models of SLE, namely NZB/W and MRL/MP-lpr/lprmice, and to try to relate this to estrogen receptor function in vivo. It is hypothesized that estradiol (EP), through its receptors, mediates the progression of murine SLE and that in autoimmune disease, the estrogen receptor is functionally or structurally changed, or both. Initial studies suggest there are differences in estrogen receptors between BALB/c mice, which donot get autoimmune disease, and two strains that do, MRL/MP-lpr/lpr and NZB/W mice. There is evidence that in at least one model of SLE, the normal regulation of estrogen action by progesterone may be impaired. In several laboratories, attempts are being made to relate estrogen action to immune function and to autoimmune diseases. The study of estrogen action on the immune system may lead to the development of treatments that attenuate the immunostimulant effects of Ep in autoimmune diseases such as SLE.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 14:48:45