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Titolo:
Simplified methods for estimation of Tc-99m-pentetate and I-131-orthoiodohippurate plasma clearance in dogs and cats
Autore:
Barthez, PY; Chew, DJ; DiBartola, SP;
Indirizzi:
Ohio State Univ, Coll Vet Med, Dept Vet Clin Sci, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 et Clin Sci, Columbus, OH 43210 USA
Titolo Testata:
JOURNAL OF VETERINARY INTERNAL MEDICINE
fascicolo: 3, volume: 15, anno: 2001,
pagine: 200 - 208
SICI:
0891-6640(200105/06)15:3<200:SMFEOT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOMERULAR-FILTRATION-RATE; SINGLE-INJECTION; RENAL-FUNCTION; TC-99M-DIETHYLENETRIAMINEPENTAACETIC ACID; FLOW; DTPA; ORTHOIODOHIPPURATE; TC-99M-DTPA; INULIN; HORSES;
Keywords:
diethylenetriaminepentacetic acid; glomerular filtration rate; hippuran; inulin; renal blood flow;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Barthez, PY Ecole Natl Vet Lyon, Dept Anim Companie, 1 Ave Bourgelat,BP 83, F-69280 Marcy Letoile, France Ecole Natl Vet Lyon 1 Ave Bourgelat,BP 83 Marcy Letoile France F-69280
Citazione:
P.Y. Barthez et al., "Simplified methods for estimation of Tc-99m-pentetate and I-131-orthoiodohippurate plasma clearance in dogs and cats", J VET INT M, 15(3), 2001, pp. 200-208

Abstract

The purpose of this study was to evaluate simplified methods for estimation of Technetium Tc 99m (Tc-99m)-pentetate and orthoiodohippurate I 131 (I-131-OIH) plasma clearance in dogs and cats with 1 and 2 blood samples. Plasma clearances were calculated after a bolus injection of 1.85-11.1 MBq of Tc-130-pentetate and I-131-OIH with a 2-compartment model based on a 12-pointcurve as a reference method in 21 dogs and 18 cats. Three 2-sample and 3 single-sample methods were investigated. The method yielding the smallest standard deviation of the difference between the reference method and the simplified method was selected as the optimal one. Linear regression analysis was performed between the reference method and tilt: simplified method and coefficient of determination (R-2) was calculated. Fur Tc-130-pentrlatr plasma clearance. die optimal 2-sample method was the one with a mono-compartment model with samples taken at specific times. For I-131-OIH plasma clearance. the estimation was improved slightly by raising the clearance calculated with a monocompartment model to the power of an empirically determined parameter The optimal single-sample method was the one with a linear quadratic regression between the volume oi distribution oi the tracer at 1! specific time and the clearance calculated with 12 samples. Two-sample methods performed significantly better than did single-sample methods. The conclusionis made that Te-99m-pentetate and I-131-OIH plasma clearances can be estimated in dogs and cats with 1 or 2 blood samples With a reasonable margin oferror compared to plasma clearances calculated with a 2-compartment model and 12 blood samples.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:16:28