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Titolo:
Retrospective study of orthovoltage radiation therapy for nasal tumors in 42 dogs
Autore:
Northrup, NC; Etue, SM; Ruslander, DM; Rassnick, KM; Hutto, DL; Bengtson, A; Rand, W; Moore, AS;
Indirizzi:
Tufts Univ, Sch Vet Med, Harrington Oncol Program, N Grafton, MA 01536 USATufts Univ N Grafton MA USA 01536 Oncol Program, N Grafton, MA 01536 USA Tufts Univ, Sch Vet Med, Sect Radiol, N Grafton, MA 01536 USA Tufts Univ N Grafton MA USA 01536 d, Sect Radiol, N Grafton, MA 01536 USA Tufts Univ, Sch Vet Med, Sect Pathol, N Grafton, MA 01536 USA Tufts Univ N Grafton MA USA 01536 d, Sect Pathol, N Grafton, MA 01536 USA Tufts Univ, Sch Vet Med, Dept Community Hlth, N Grafton, MA 01536 USA Tufts Univ N Grafton MA USA 01536 Community Hlth, N Grafton, MA 01536 USA
Titolo Testata:
JOURNAL OF VETERINARY INTERNAL MEDICINE
fascicolo: 3, volume: 15, anno: 2001,
pagine: 183 - 189
SICI:
0891-6640(200105/06)15:3<183:RSOORT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALIGNANT CANINE NASAL; MEGAVOLTAGE IRRADIATION; INTRANASAL NEOPLASMS; RADIOTHERAPY; SURVIVAL; ADENOCARCINOMA; CAVITIES;
Keywords:
cancer; canine; neoplasia; respiratory;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Northrup, NC Univ Georgia, Coll Vet Med, Dept Small Anim Med, Athens, GA 30602 USA Univ Georgia Athens GA USA 30602 m Med, Athens, GA 30602 USA
Citazione:
N.C. Northrup et al., "Retrospective study of orthovoltage radiation therapy for nasal tumors in 42 dogs", J VET INT M, 15(3), 2001, pp. 183-189

Abstract

Megavoltage radiation therapy currently is the standard of care for dogs with nasal tumors. Some studies report that surgery and adjunctive orthovoltage radiation therapy result in longer control of these tumors than does megavoltage radiation therapy alone. This study reports less effective control of nasal tumors in dogs treated with surgery and orthovoltage radiation than previously observed, supporting the superiority of megavoltage radiation therapy for these tumors. In addition, this study suggests 2 new prognostic indicators for dogs with nasal rumors and describes toxicity associated with surgery and orthovoltage therapy. Forty two dogs with nasal rumors were treated with surgical cytoreduction and 48 Gy orthovoltage radiation therapy administered in twelve 4-Gy fractions. Median survival was 7.4 months. One- and 2-year survival rates were 37% and 17% respectively. Dogs with facial deformity had shorter survival than those without deformity (P = .005). Dogs with resolution of clinical signs after treatment had longer survivalthan those with chronic nasal signs (P = .0001). Acute radiation toxicity was moderate to severe for skin and eye and negligible for oral mucosa. Toxicity healed within 1 month after radiation therapy. Late toxicity was mild, but 70% of evaluable dogs experienced persistent ocular signs. Only 39% of dogs achieved a disease-free period.

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Documento generato il 25/11/20 alle ore 10:18:39