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Titolo:
Comparison of peripheral inhibitory effects of clomipramine with selectiveserotonin re-uptake inhibitors on contraction of vas deferens: In vitro and in vivo studies
Autore:
Seo, KK; Kim, SC; Lee, MY;
Indirizzi:
Chung Ang Univ, Coll Med, Dept Urol & Physiol, Seoul 156756, South Korea Chung Ang Univ Seoul South Korea 156756 ysiol, Seoul 156756, South Korea
Titolo Testata:
JOURNAL OF UROLOGY
fascicolo: 6, volume: 165, anno: 2001,
parte:, 1
pagine: 2110 - 2114
SICI:
0022-5347(200106)165:6<2110:COPIEO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREMATURE EJACULATION; ANTIDEPRESSANT DRUGS; DOUBLE-BLIND; RAT; FLUOXETINE; RECEPTORS; MUSCLE; NEUROTRANSMISSION; FLUVOXAMINE; SERTRALINE;
Keywords:
vas deferens; clomipramine; ejaculation; serotonin uptake inhibitors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Seo, KK Chung Ang Univ, Coll Med, Dept Urol & Physiol, Seoul 156756, SouthKorea Chung Ang Univ Seoul South Korea 156756 eoul 156756, South Korea
Citazione:
K.K. Seo et al., "Comparison of peripheral inhibitory effects of clomipramine with selectiveserotonin re-uptake inhibitors on contraction of vas deferens: In vitro and in vivo studies", J UROL, 165(6), 2001, pp. 2110-2114

Abstract

Purpose: We compared the peripheral inhibitory effects of the tricyclic antidepressant clomipramine with those of various selective serotonin re-uptake inhibitors on the contractile response of the vas deferens. Materials and Methods: The contractile responses of 17 circular smooth muscle strips of human vas deferens to 10(-4) M. norepinephrine were observed in the absence and presence of clomipramine, and the selective serotonin re-uptake inhibitors fluoxetine, sertraline and paroxetine. The intraluminal pressure response of rat vas deferens to electrical stimulation of the hypogastric nerve was measured in 5 rats in the central plus peripheral effect group before and after the intravenous injection of 4.2 mg./kg. clomipramine or 8.3 mg./kg. sertraline. The pressure response to each agent was also observed after the transection of all proximal sympathetic input to the hypogastric nerve in 5 animals in the peripheral effect group. Results: Clomipramine was about 100-fold more potent than sertraline, fluoxetine or paroxetine for inhibiting the norepinephrine induced contraction of human vasal muscle strips. The inhibitory effect of sertraline on rat intravasal pressure in the peripheral effect group was significantly lower than in the central plus peripheral effect group (p <0.05), while no significant difference was noted in the 2 groups regarding clomipramine. The effectof clomipramine was significantly higher than that of sertraline in the central plus peripheral and peripheral effect groups (p <0.01). Conclusions: Differences in potency of the peripheral inhibitory effects of the selective serotonin re-uptake inhibitors and clomipramine may contribute to their differential effects on delaying ejaculatory latency in patients with premature ejaculation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 09:21:36