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Titolo:
Increased plasma norepinephrine concentration in cats with interstitial cystitis
Autore:
Buffington, CAT; Pacak, K;
Indirizzi:
Ohio State Univ, Coll Vet Med, Dept Vet Clin Sci, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 et Clin Sci, Columbus, OH 43210 USA NICHHD, Pediat & Reprod Endocrinol Branch, Bethesda, MD 20892 USA NICHHD Bethesda MD USA 20892 od Endocrinol Branch, Bethesda, MD 20892 USA
Titolo Testata:
JOURNAL OF UROLOGY
fascicolo: 6, volume: 165, anno: 2001,
parte:, 1
pagine: 2051 - 2054
SICI:
0022-5347(200106)165:6<2051:IPNCIC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCUS-COERULEUS; ELECTROCHEMICAL DETECTION; PARAVENTRICULAR NUCLEUS; LIQUID-CHROMATOGRAPHY; NERVOUS-SYSTEM; STRESS; AMITRIPTYLINE; NEURONS; CATECHOLAMINES; MICRODIALYSIS;
Keywords:
bladder; cystitis, interstitial; norepinephrine; cats; sympathetic nervous system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Buffington, CAT Ohio State Univ, Coll Vet Med, Dept Vet Clin Sci, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 umbus, OH 43210 USA
Citazione:
C.A.T. Buffington e K. Pacak, "Increased plasma norepinephrine concentration in cats with interstitial cystitis", J UROL, 165(6), 2001, pp. 2051-2054

Abstract

Purpose: Interstitial cystitis is a chronic urological syndrome affecting humans and domestic animals, including cats (feline interstitial cystitis). The symptoms of interstitial cystitis seem to be exacerbated by stress, suggesting involvement of the sympathetic nervous system and/or hypothalamic-pituitary-adrenal axis. Others have described sympathetic nervous system abnormalities in patients with interstitial cystitis but to our knowledge no data on plasma catecholamine concentrations or hyp othalamic-pituitary-adrenal axis function in such patients have been reported. To evaluate the roleof these systems in cats with feline interstitial cystitis we simultaneously measured baseline plasma concentrations of catecholamines and their metabolites to assess sympathetic activity, and the response of plasma adenocorticotropic hormone and cortisol concentrations to the infusion of corticotropin-releasing factor. Materials and Methods: Eight healthy cats and 8 with feline interstitial cystitis were anesthetized and a catheter was placed in the external jugularvein. Four hours after recovery samples were obtained for high performanceliquid chromatography analysis of plasma norepinephrine, dihydroxyphenylglycol, epinephrine, dihydroxyphenylalanine, dopamine and dihydroxyphenylacetic acid. In 4 cats per group 1 mug. ovine corticotropin-releasing factor per kg. body weight was infused and blood samples were collected at intervalsfor 120 minutes for determining adenocorticotropic hormone and cortisol. Results: Significant increases in plasma norepinephrine and dihydroxyphenylglycol as well as a trend toward increased epinephrine were found, whereasno effect on dihydroxyphenylalanine, dopamine, dihydroxyphenylacetic acid,adenocorticotropic hormone or cortisol was identified in cats with feline interstitial cystitis. Conclusions: These results support and extend previous studies identifyingan increase in sympathetic activity in cats with feline interstitial cystitis.

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Documento generato il 30/03/20 alle ore 19:17:25