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Titolo:
High-energy diets, fatty acids and endothelial cell function: Implicationsfor atherosclerosis
Autore:
Henning, B; Toborek, M; McClain, CJ;
Indirizzi:
Univ Kentucky, Coll Agr, Dept Anim Sci, Cell Nutr Grp, Lexington, KY 40506USA Univ Kentucky Lexington KY USA 40506 ell Nutr Grp, Lexington, KY 40506USA Univ Kentucky, Dept Surg, Lexington, KY 40506 USA Univ Kentucky LexingtonKY USA 40506 , Dept Surg, Lexington, KY 40506 USA Univ Kentucky, Grad Ctr Nutr Sci & Toxicol, Lexington, KY 40506 USA Univ Kentucky Lexington KY USA 40506 i & Toxicol, Lexington, KY 40506 USA Univ Louisville, Dept Med, Louisville, KY 40292 USA Univ Louisville Louisville KY USA 40292 ept Med, Louisville, KY 40292 USA
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
fascicolo: 2, volume: 20, anno: 2001,
pagine: 97 - 105
SICI:
0731-5724(200104)20:2<97:HDFAAE>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; TRIGLYCERIDE-RICH LIPOPROTEINS; NF-KAPPA-B; TISSUE-SPECIFIC EXPRESSION; CORONARY-ARTERY DISEASE; ZINC-DEFICIENT RATS; VITAMIN-E; LINOLEIC-ACID; LIPID-PEROXIDATION; ALPHA-TOCOPHEROL;
Keywords:
high-energy diets; hypertriglyceridemia; postprandial lipemia; fatty acids; endothelial cell dysfunction; atherosclerosis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
112
Recensione:
Indirizzi per estratti:
Indirizzo: Henning, B Univ Kentucky, Coll Agr, Dept Anim Sci, Cell Nutr Grp, 204 Funkhouser Bldg, Lexington, KY 40506 USA Univ Kentucky 204 Funkhouser Bldg Lexington KY USA 40506 06 USA
Citazione:
B. Henning et al., "High-energy diets, fatty acids and endothelial cell function: Implicationsfor atherosclerosis", J AM COL N, 20(2), 2001, pp. 97-105

Abstract

Diets high in fat and/or calories can lead to hypertriglyceridemia and postprandial lipemia and thus are considered a risk factor for the developmentof atherosclerosis. Plasma chylomicron levels are elevated in humans afterconsuming a high-fat meal, and hepatic synthesis of VLDL is increased whencaloric intake is in excess of body needs. High lipoprotein lipase activity and subsequent hydrolysis of triglyceride-rich lipoproteins may be an important source of elevated concentrations of fatty acid anions in the proximity to the endothelium and hence a major risk factor for atherosclerosis. We have shown that selected fatty acids, as well as lipoprotein in lipase-derived remnants of lipoproteins isolated from hypertriglyceridemic subjects,can activate vascular endothelial cells and disrupt endothelial integrity. Our studies suggest that omega-6 fatty acids, and especially linoleic acid, cause endothelial cell dysfunction most markedly as well as can potentiate TNF-mediated endothelial cell injury. We propose that high-energy diets, and especially diets rich in lipoleic acid, are atherogenic by contributingto an imbalance in cellular oxidate stress/antioxidant status of the endothelium, which can lead to activation of oxidative stress-responsive transcription factors, inflammatory cytokine production and the expression of adhesion molecules. Our data also suggest that nutrients, which have antioxidant and/or membrane stabilizing properties, can protect endothelial cells. These findings contribute to the understanding of the interactive role of high fat/calorie diets and subsequent hypertriglyceridemia with inflammatory components and nutrients that exhibit antiatherogenic properties in the development of atherosclerosis. Moreover, results from our research further support the concept that high-fat/calorie diets and associated postprandial hypertriglyceridemia are significant risk factors for atherosclerosis.

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Documento generato il 27/01/20 alle ore 07:31:49